Hunt J R, Penland J G
United States Department of Agriculture's Agricultural Research Service, Human Nutrition Research Center, Grand Forks, North Dakota, USA.
Behav Med. 1999 Summer;25(2):62-8. doi: 10.1080/08964289909595738.
To test the hypothesis that low iron status or other nutritional deficiencies are associated with symptoms of depression in premenopausal women, the authors related blood indices of iron status to scores on the Minnesota Multiphasic Personality Inventory (MMPI) and responses to a mood adjective checklist. Participants recruited locally provided fasting blood samples and completed the MMPI during the follicular phase of the menstrual cycle. Of 365 apparently healthy participants, 4% had hemoglobin < 120 g/L, 6% had transferrin saturation < 16%, 20% had ferritin < 12 micrograms/L, and 8% had clinically elevated scores (T > or = 70) on the Depression scale of the MMPI. The frequency of elevated MMPI Depression scores was unrelated to the frequency of low hemoglobin, transferrin saturation, or ferritin. The results do not support the hypothesis that low iron status contributes to symptoms of depression in women.
为了验证绝经前女性铁缺乏状态或其他营养缺乏与抑郁症状相关这一假设，作者将铁状态的血液指标与明尼苏达多相人格调查表（MMPI）得分以及对情绪形容词清单的反应进行了关联分析。在当地招募的参与者在月经周期的卵泡期提供了空腹血样并完成了MMPI测试。在365名看似健康的参与者中，4%的人血红蛋白<120 g/L，6%的人转铁蛋白饱和度<16%，20%的人铁蛋白<12微克/L，8%的人在MMPI抑郁量表上的临床得分（T≥70）升高。MMPI抑郁得分升高的频率与低血红蛋白、转铁蛋白饱和度或铁蛋白的频率无关。研究结果不支持铁缺乏状态导致女性抑郁症状这一假设。
