Amiel G E, Sukhotnik I, Kawar B, Siplovich L
Department of Urology, Bnai Zion Medical Center, Bruce Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa, Israel.
J Am Coll Surg. 1999 Jul;189(1):21-5. doi: 10.1016/s1072-7515(99)00068-x.
Histoacryl Blue (N-butyl-2-cyanoacrylate) is a tissue adhesive that has been used clinically for more than 20 years. In the last decade, N-butyl-2-cyanoacrylate has been used for cutaneous closure of low-tension lacerations in children and adults and has become a preferred method for closure of pediatric facial lacerations in many emergency rooms outside the United States. Many pediatric elective surgical procedures are performed in tension-free areas and may be suitable for closure with a tissue adhesive. In order to assess this approach, a retrospective study was conducted to evaluate the cosmetic outcomes and complications of the application of N-butyl-2-cyanoacrylate for the approximation of elective surgical incisions in a pediatric population.
Records of 1,098 patients, ages 1 month to 16 years, who, between January 1995 and December 1996, underwent one of the following: orchidopexy, inguinal hernia, umbilical hernia, or hydrocele repair were analyzed. In all patients, N-butyl-2-cyanoacrylate was applied to close the surgical incision. A 12-item questionnaire was created to assess the presence of complications and to determine shortterm and longterm cosmetic outcomes of the incision. Data were collected by conducting telephone interviews of family members.
Among the 1,033 children who were treated, 66% had inguinal hernias, 15% hydroceles, 15% undescended testis, and 4% umbilical hernias. Redness or tenderness at the incision site (5.5%), discharge from the surgical wound (1.9%), and wound dehiscence (1.1%) were the main immediate complications after surgery. Overall satisfaction with the cosmetic outcomes of the surgical scar was high, with an average score of 4.73 out of 5 (94.6%).
Our results demonstrate that administration of N-butyl-2-cyanoacrylate for the closure of small low-tension surgical incisions in the pediatric population is safe, has a low complication rate, and produces excellent cosmetic outcomes.
Histoacryl Blue（N-丁基-2-氰基丙烯酸酯）是一种组织粘合剂，已在临床上使用超过20年。在过去十年中，N-丁基-2-氰基丙烯酸酯已用于儿童和成人低张力伤口的皮肤缝合，并且在美国以外的许多急诊室已成为小儿面部伤口缝合的首选方法。许多小儿择期外科手术在无张力区域进行，可能适合用组织粘合剂进行缝合。为了评估这种方法，进行了一项回顾性研究，以评估N-丁基-2-氰基丙烯酸酯用于小儿择期手术切口缝合的美容效果和并发症。
分析了1995年1月至1996年12月期间1098例年龄在1个月至16岁之间的患者的记录，这些患者接受了以下手术之一：睾丸固定术、腹股沟疝修补术、脐疝修补术或鞘膜积液修补术。在所有患者中，使用N-丁基-2-氰基丙烯酸酯闭合手术切口。创建了一份包含12个项目的问卷，以评估并发症的存在情况，并确定切口的短期和长期美容效果。通过对家庭成员进行电话访谈收集数据。
在接受治疗的1033名儿童中，66%患有腹股沟疝，鞘膜积液占15%，隐睾占15%，脐疝占4%。切口部位发红或压痛（5.5%）、手术伤口渗液（1.9%）和伤口裂开（1.1%）是术后主要的即刻并发症。对手术疤痕美容效果的总体满意度较高，平均得分为4.73分（满分5分，占94.6%）。
我们的结果表明，在小儿群体中使用N-丁基-2-氰基丙烯酸酯闭合小的低张力手术切口是安全的，并发症发生率低，并且产生优异的美容效果。
