弗里德里希共济失调患者齿状核中铁含量增加。
Increased iron in the dentate nucleus of patients with Friedrich's ataxia.
作者信息
Waldvogel D, van Gelderen P, Hallett M
机构信息
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1428, USA.
出版信息
Ann Neurol. 1999 Jul;46(1):123-5. doi: 10.1002/1531-8249(199907)46:1<123::aid-ana19>3.0.co;2-h.
Friedreich's ataxia (FA) is the most frequently inherited ataxia. To test the hypothesis that iron is increased in the cerebellum of patients with FA, we developed a multigradient echo magnetic resonance sequence for the three-dimensional imaging of brain iron-induced contrast. Relaxation rate (R2*) values in the unaffected globus pallidus were equal in FA patients and controls, although R2* values in the dentate nucleus of patients were significantly higher, which is most likely due to increased iron.
弗里德赖希共济失调（FA）是最常见的遗传性共济失调。为了验证FA患者小脑中铁含量增加这一假说，我们开发了一种多梯度回波磁共振序列，用于脑铁诱导对比的三维成像。FA患者和对照组中未受影响的苍白球的弛豫率（R2*）值相等，尽管患者齿状核中的R2*值显著更高，这很可能是由于铁含量增加所致。
Zotero 插件