Nilsen K E, Russell I J
School of Biological Sciences, University of Sussex, Falmer, Brighton, UK.
Nat Neurosci. 1999 Jul;2(7):642-8. doi: 10.1038/10197.
Electromotile outer hair cell (OHC) feedback provides the sensitivity and sharp frequency tuning of the cochlea. Basilar membrane displacements in response to characteristic frequency (CF) tones were measured with an interferometer at up to 15 locations across the basilar membrane width in the basal turn of the guinea pig cochlea. For CF tones, basilar membranes vibrations were largest beneath the OHCs; these phase-led vibrations beneath outer pillar cells and adjacent to the spiral ligament by approximately 90 degrees. Post mortem, responses measured beneath the OHCs were reduced by up to 65 dB, and the basilar membrane moved with similar phase across its entire width. We suggest OHCs amplify basilar membrane responses to CF tones when the basilar membrane moves at maximum velocity.
电动外毛细胞（OHC）反馈提供了耳蜗的灵敏度和尖锐的频率调谐。在豚鼠耳蜗基部转弯处，使用干涉仪在基底膜宽度上多达15个位置测量了响应特征频率（CF）音调的基底膜位移。对于CF音调，基底膜振动在OHC下方最大；这些在外柱细胞下方并与螺旋韧带相邻的振动相位超前约90度。死后，在OHC下方测量的响应降低了多达65 dB，并且基底膜在其整个宽度上以相似的相位移动。我们认为，当基底膜以最大速度移动时，OHC会放大基底膜对CF音调的响应。
