Przytycka T, Aurora R, Rose G D
Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Nat Struct Biol. 1999 Jul;6(7):672-82. doi: 10.1038/10728.
Does a protein's secondary structure determine its three-dimensional fold? This question is tested directly by analyzing proteins of known structure and constructing a taxonomy based solely on secondary structure. The taxonomy is generated automatically, and it takes the form of a tree in which proteins with similar secondary structure occupy neighboring leaves. Our tree is largely in agreement with results from the structural classification of proteins (SCOP), a multidimensional classification based on homologous sequences, full three-dimensional structure, information about chemistry and evolution, and human judgment. Our findings suggest a simple mechanism of protein evolution.
蛋白质的二级结构决定其三维折叠吗？通过分析已知结构的蛋白质并仅基于二级结构构建分类法，这个问题得到了直接检验。分类法是自动生成的，其形式为一棵树，具有相似二级结构的蛋白质占据相邻的叶节点。我们的树状图在很大程度上与蛋白质结构分类（SCOP）的结果一致，SCOP是一种基于同源序列、完整三维结构、化学和进化信息以及人类判断的多维分类法。我们的研究结果提示了一种简单的蛋白质进化机制。
