Kessing L V, Andersen P K
Department of Psychiatry, University of Copenhagen, Rigshospitalet, Denmark.
J Affect Disord. 1999 Jun;53(3):225-31. doi: 10.1016/s0165-0327(98)00125-6.
The risk of recurrence has been found to increase with the number of episodes in both unipolar and bipolar affective disorder. The present study compared the effect of the number of episodes on the risk of recurrence in the two disorders.
A case register study including all hospital admissions with primary affective disorder in Denmark during 1971-1993. The effect of the number of prior episodes on the rate of recurrence following the first discharge after 1984 was estimated. A total of 7925 unipolar patients and 2011 bipolar patients were included in the study.
The rate of recurrence was, on average, 1.6 times greater for bipolar patients than for unipolar patients. Nevertheless, the effect of the number of episodes was greatest for unipolar patients. Thus, the rate of recurrence increased, on average, 15% with every episode for unipolar patients and 9% with every episode for bipolar patients, when adjusted for differences in age and gender.
The risk of recurrence increases with every new episode in affective disorder. The effect of episodes is greater for unipolar disorder than for bipolar disorder.
The data relate to re-admissions rather than recurrence.
The study shows that the prognosis worsens more for unipolar than for bipolar patients with each new episode and suggests the relevance of earlier and more sustained intervention.
在单相和双相情感障碍中，复发风险均已被发现会随着发作次数的增加而升高。本研究比较了发作次数对这两种疾病复发风险的影响。
一项病例登记研究，纳入了1971年至1993年丹麦所有因原发性情感障碍住院的患者。评估了既往发作次数对1984年后首次出院后复发率的影响。该研究共纳入了7925名单相情感障碍患者和2011名双相情感障碍患者。
双相情感障碍患者的平均复发率比单相情感障碍患者高1.6倍。然而，发作次数对单相情感障碍患者的影响最大。因此，在调整年龄和性别差异后，单相情感障碍患者每次发作的复发率平均增加15%，双相情感障碍患者每次发作的复发率平均增加9%。
情感障碍的复发风险随着每一次新发作而增加。发作次数对单相情感障碍的影响大于双相情感障碍。
数据涉及再次入院而非复发。
该研究表明，单相情感障碍患者每次新发作的预后比双相情感障碍患者恶化得更严重，并提示早期和更持续干预的相关性。
