抑郁症患者和双相情感障碍患者患痴呆症的风险是否会随着发作次数的增加而增加？
Does the risk of developing dementia increase with the number of episodes in patients with depressive disorder and in patients with bipolar disorder?
作者信息
Kessing L V, Andersen P K
机构信息
Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark.
出版信息
J Neurol Neurosurg Psychiatry. 2004 Dec;75(12):1662-6. doi: 10.1136/jnnp.2003.031773.
OBJECTIVE
Several findings suggest that some patients with depressive or bipolar disorder may be at increased risk of developing dementia. The present study aimed to investigate whether the risk of developing dementia increases with the number of affective episodes in patients with depressive disorder and in patients with bipolar disorder.
METHODS
This was a case register study including all hospital admissions with primary affective disorder in Denmark during 1970-99. The effect of the number of prior episodes leading to admission on the rate of readmission with a diagnosis of dementia following the first discharge after 1985 was estimated. A total of 18,726 patients with depressive disorder and 4248 patients with bipolar disorder were included in the study.
RESULTS
The rate of a diagnosis of dementia on readmission was significantly related to the number of prior affective episodes leading to admission. On average, the rate of dementia tended to increase 13% with every episode leading to admission for patients with depressive disorder and 6% with every episode leading to admission for patients with bipolar disorder, when adjusted for differences in age and sex.
CONCLUSION
On average, the risk of dementia seems to increase with the number of episodes in depressive and bipolar affective disorders.
目的
多项研究结果表明，一些患有抑郁症或双相情感障碍的患者患痴呆症的风险可能会增加。本研究旨在调查抑郁症患者和双相情感障碍患者患痴呆症的风险是否会随着情感发作次数的增加而增加。
方法
这是一项病例登记研究，纳入了1970年至1999年期间丹麦所有因原发性情感障碍住院的患者。评估了导致入院的既往发作次数对1985年后首次出院后因痴呆症再次入院率的影响。该研究共纳入了18726例抑郁症患者和4248例双相情感障碍患者。
结果
再次入院时痴呆症的诊断率与导致入院的既往情感发作次数显著相关。在调整年龄和性别差异后，平均而言，抑郁症患者每一次导致入院的发作，痴呆症发病率往往增加13%，双相情感障碍患者每一次导致入院的发作，痴呆症发病率增加6%。
结论
平均而言，痴呆症的风险似乎会随着抑郁和双相情感障碍发作次数的增加而增加。
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