Kessing L V, Mortensen P B
Department of Psychiatry, University of Copenhagen, Rigshospitalet, Denmark.
Acta Psychiatr Scand. 1999 Oct;100(4):279-87. doi: 10.1111/j.1600-0447.1999.tb10862.x.
The aim of the study was to investigate whether the duration of treated episodes changes during the course of unipolar and bipolar affective disorder.
The rate of recovery from successive hospitalized episodes was estimated with survival analyses in a case-register study including all hospital admissions with primary affective disorder in Denmark during the period 1971-1993.
A total of 9174 patients with recurrent episodes were followed from their first admission. The rate of recovery from hospitalized episodes did not change with the number of episodes in unipolar or bipolar disorder. Furthermore, the rate of recovery was constant across episodes, regardless of the combination of age, gender and type of disorder. Initially in the course of the illness, the rate was a little faster for bipolar than for unipolar patients, but later in the course of the illness the rate of recovery was the same for the two disorders.
It is concluded that, in modern treatment settings, the duration of affective episodes appears to be stable during the course of unipolar and bipolar disorder.
本研究旨在调查单相和双相情感障碍病程中治疗发作的持续时间是否发生变化。
在一项病例登记研究中,采用生存分析估计连续住院发作的康复率,该研究纳入了1971年至1993年丹麦所有因原发性情感障碍住院的患者。
共有9174例复发性发作患者从首次入院开始随访。单相或双相情感障碍住院发作的康复率并不随发作次数而变化。此外,无论年龄、性别和障碍类型如何组合,各次发作的康复率都是恒定的。在疾病病程初期,双相情感障碍患者的康复率比单相情感障碍患者略快,但在疾病后期,两种障碍的康复率相同。
得出结论,在现代治疗环境中,单相和双相情感障碍病程中情感发作的持续时间似乎是稳定的。