Liu A, Williams L E, Lopatin G, Yamauchi D M, Wong J Y, Raubitschek A A
Department of Radioimmunotherapy, City of Hope National Medical Center, Duarte, California 91010, USA.
J Nucl Med. 1999 Jul;40(7):1151-3.
An object-oriented software system is described for estimating internal emitter absorbed doses using a set of computer modules operating within a personal computer environment. The system is called the Radionuclide Treatment Planning and Absorbed Dose Estimation System (RTDS). It is intended for radioimmunotherapy applications, although other forms of internal emitter therapy may also be considered.
Four software modules interact through a database backend. Clinical, demographic and image data are directly entered into the database. Modules include those devoted to clinical imaging (nuclear, CT and MR), activity determination, organ compartmental modeling and absorbed dose estimation.
Both standard phantom (Medical Internal Radiation Dose [MIRD]) and patient-specific absorbed doses are estimated. All modules interact with the database backend so that changes in one process do not influence other operations. Results of the modular operations are written to the database as computations are completed. Dose-volume histograms are an intrinsic part of the output for patient-specific absorbed dose estimates. A sample dose estimate for a potential 90Y monoclonal antibody is described.
A four-module software system has been implemented to estimate MIRD phantom and patient-specific absorbed doses. Computations of the doses and their statistical distribution for a pure beta emitter such as 90Y take approximately 1 min on a 300 MHz personal computer.
描述了一种面向对象的软件系统，该系统使用在个人计算机环境中运行的一组计算机模块来估计内部发射体的吸收剂量。该系统称为放射性核素治疗计划与吸收剂量估计系统（RTDS）。它适用于放射免疫治疗应用，不过也可考虑其他形式的内部发射体治疗。
四个软件模块通过数据库后端进行交互。临床、人口统计学和图像数据直接输入数据库。模块包括致力于临床成像（核医学、CT和MR）、活度确定、器官分区建模和吸收剂量估计的模块。
估计了标准体模（医学内部辐射剂量[MIRD]）和患者特异性吸收剂量。所有模块都与数据库后端交互，因此一个过程中的变化不会影响其他操作。模块化操作的结果在计算完成后写入数据库。剂量体积直方图是患者特异性吸收剂量估计输出的固有组成部分。描述了针对潜在的90Y单克隆抗体的样本剂量估计。
已实施一个四模块软件系统来估计MIRD体模和患者特异性吸收剂量。对于像90Y这样的纯β发射体，在一台300 MHz的个人计算机上计算剂量及其统计分布大约需要1分钟。
