Wessels Barry W, Syh Joseph H, Meredith Ruby F
Department of Radiation Oncology, Comprehensive Cancer Care Center, Case Western Reserve University, Cleveland, OH, USA.
Int J Radiat Oncol Biol Phys. 2006;66(2 Suppl):S39-45. doi: 10.1016/j.ijrobp.2006.05.069.
The purposes of systemic targeted radionuclide therapy dosimetry include compiling a database of normal organ radiation-absorbed doses that are carrier- and radionuclide-specific, and assuring that the normal organ radiation doses are within a safe range before therapy. Also of importance is quantitation of radiation delivery to tumors vs. normal tissues to correlate absorbed dose with tumor control. For agents with significant and variable excretion, estimates of individual patient distribution/clearance may be needed to optimize the dose-response relationship.
全身靶向放射性核素治疗剂量测定的目的包括汇编特定载体和放射性核素的正常器官辐射吸收剂量数据库，并确保在治疗前正常器官的辐射剂量在安全范围内。同样重要的是对肿瘤与正常组织的辐射剂量进行定量，以将吸收剂量与肿瘤控制相关联。对于具有显著且可变排泄的药物，可能需要估计个体患者的分布/清除情况，以优化剂量反应关系。
