纤维肌痛患者脑脊液中神经生长因子浓度升高。
Increased concentrations of nerve growth factor in cerebrospinal fluid of patients with fibromyalgia.
作者信息
Giovengo S L, Russell I J, Larson A A
机构信息
Department of Veterinary Pathobiology, University of Minnesota, St. Paul 55108, USA.
出版信息
J Rheumatol. 1999 Jul;26(7):1564-9.
OBJECTIVE
To determine whether there is a difference in the concentration of nerve growth factor (NGF) in the cerebrospinal fluid (CSF) from patients diagnosed with primary fibromyalgia syndrome (FM), fibromyalgia associated with other secondary conditions (SFM), patients with other painful conditions but lacking fibromyalgia (OTHER), and healthy controls.
METHODS
The clinical measures of pain threshold included the tender point index, a measure of pain threshold intensity measured by digital pressure, and the average pain threshold measured by dolorimetry. Concentrations of NGF in the CSF were measured using a 2 site enzyme immunoassay.
RESULTS
The mean (+/- SEM) concentration of NGF measured in patients with FM was significantly increased (41.8 +/- 12.7 pg/ml) compared to controls (9.1 +/- 4.1 pg/ml), but with large variability. Concentrations of NGF is SFM (8.9 +/- 4.4 pg/ml) and OTHER (16.2 +/- 8.4 pg/ml) were not elevated compared to controls.
CONCLUSION
The findings of increased concentrations of NGF in patients with FM suggest a central mechanism, involving abnormalities in neuropeptides such as NGF, may be a factor in the pathogenesis of FM.
目的
确定被诊断为原发性纤维肌痛综合征（FM）、与其他继发疾病相关的纤维肌痛（SFM）、患有其他疼痛性疾病但无纤维肌痛的患者（OTHER）以及健康对照者的脑脊液（CSF）中神经生长因子（NGF）浓度是否存在差异。
方法
疼痛阈值的临床测量包括压痛点指数，即通过数字压力测量的疼痛阈值强度指标，以及通过痛觉计测量的平均疼痛阈值。使用双位点酶免疫测定法测量脑脊液中NGF的浓度。
结果
与对照组（9.1±4.1 pg/ml）相比，FM患者中测量的NGF平均（±SEM）浓度显著升高（41.8±12.7 pg/ml），但存在较大变异性。与对照组相比，SFM（8.9±4.4 pg/ml）和OTHER（16.2±8.4 pg/ml）中NGF的浓度没有升高。
结论
FM患者中NGF浓度升高的发现表明，涉及NGF等神经肽异常的中枢机制可能是FM发病机制中的一个因素。
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