Matera A G
Dept of Genetics, Center for Human Genetics and Program in Cell Biology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106-4955, USA.
Trends Cell Biol. 1999 Aug;9(8):302-9. doi: 10.1016/s0962-8924(99)01606-2.
Higher-eukaryotic nuclei contain numerous morphologically distinct substructures that are collectively called nuclear bodies. Although the precise functions of these subdomains remain unknown, elucidation of their molecular composition has been the subject of a great deal of research in recent years. Changes in the constitution of these nuclear inclusions are associated with disease phenotypes. The wide variety of components that concentrate within these subdomains makes them a likely interface for multiple cellular processes, including transcription, RNA processing, transport, RNP assembly, protein modification, apoptosis and cell-cycle control. This review discusses the different types of nuclear bodies, with emphasis on the two most prominent subtypes - the coiled and PML bodies.
高等真核生物的细胞核包含众多形态各异的亚结构，这些亚结构统称为核体。尽管这些亚结构域的确切功能尚不清楚，但近年来对其分子组成的阐明一直是大量研究的主题。这些核内含物组成的变化与疾病表型相关。集中在这些亚结构域内的各种成分使其成为多种细胞过程的可能界面，包括转录、RNA加工、运输、核糖核蛋白组装、蛋白质修饰、细胞凋亡和细胞周期控制。本综述讨论了不同类型的核体，重点是两种最突出的亚型——卷曲体和早幼粒细胞白血病蛋白体。
