Jones H C
University of Texas Health Science Center, San Antonio, USA.
Fam Med. 1999 May;31(5):327-30.
Methadone maintenance is the standard of care for pregnant opiate addicts. However, withdrawal of an infant from methadone after birth often results in a lengthy hospital stay. This study identified potentially modifiable factors that are associated with the length of hospital stay of infants of mothers on methadone.
This study used a retrospective case series of patients from a university hospital in Texas. Eligible participants included 41 neonates born between January 1991 and December 1996 to mothers taking methadone at time of delivery. Charts were reviewed for factors relating to administration of opiates to the newborn, and the length of the hospital stay was recorded for each infant. Bivariate and multiple regression analyses were performed using length of hospital stay as the outcome measure.
Higher peak dose of tincture of opiate solution (TOS) and longer dosing interval were found to be related to longer length of hospital stay. These variables explained 23% of the variation in length of stay.
Lower peak doses of TOS and shorter dosing intervals may be associated with shorter hospital stays for infants with neonatal abstinence syndrome secondary to maternal methadone treatment.
美沙酮维持治疗是孕期阿片类成瘾者的标准治疗方法。然而，婴儿出生后停用美沙酮往往会导致住院时间延长。本研究确定了与接受美沙酮治疗的母亲所生婴儿住院时间相关的潜在可改变因素。
本研究采用德克萨斯州一家大学医院患者的回顾性病例系列。符合条件的参与者包括1991年1月至1996年12月期间出生的41名新生儿，其母亲在分娩时服用美沙酮。查阅病历以获取与给新生儿使用阿片类药物相关的因素，并记录每个婴儿的住院时间。以住院时间作为结果指标进行双变量和多元回归分析。
发现阿片酊溶液（TOS）的较高峰值剂量和较长给药间隔与较长住院时间相关。这些变量解释了住院时间变异的23%。
较低的TOS峰值剂量和较短的给药间隔可能与因母亲美沙酮治疗导致新生儿戒断综合征的婴儿住院时间缩短有关。
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