Dysart Kevin, Hsieh Hui-Chen, Kaltenbach Karol, Greenspan Jay S
Department of Pediatrics, Thomas Jefferson University, Nemours Children's Clinics, Philadelphia, PA, USA.
J Perinat Med. 2007;35(4):344-6. doi: 10.1515/JPM.2007.063.
We determined the effect of preterm delivery on the course of neonatal abstinence syndrome (NAS) in infants born to mothers participating in a methadone maintenance program.
A retrospective cohort study was conducted in which infant and maternal data were collected from the medical records of 53 preterm and 66 term infants. Infants were selected from all infants admitted to Thomas Jefferson University hospital born between 1998 and 2002 whose mothers were enrolled in the methadone maintenance program. All infants were managed by a standard protocol utilizing the Neonatal Abstinence Scoring System (NASS) and neonatal opiate solution (NOS). Preterm and term infants were compared.
Preterm infants had shorter lengths of stay, treatment courses and required less medication than did term infants during the same time period.
These data indicate that following exposure to maternal methadone, preterm infants have a different neonatal course than do infants born at term.
我们确定了早产对参与美沙酮维持治疗项目的母亲所生婴儿的新生儿戒断综合征（NAS）病程的影响。
进行了一项回顾性队列研究，从53例早产婴儿和66例足月儿的病历中收集婴儿和母亲的数据。这些婴儿选自1998年至2002年间入住托马斯·杰斐逊大学医院的所有婴儿，其母亲均参与了美沙酮维持治疗项目。所有婴儿均按照使用新生儿戒断评分系统（NASS）和新生儿阿片溶液（NOS）的标准方案进行管理。对早产婴儿和足月儿进行了比较。
在同一时期，早产婴儿的住院时间、治疗疗程较短，所需药物也比足月儿少。
这些数据表明，暴露于母体美沙酮后，早产婴儿的新生儿病程与足月儿不同。
