Powers R E
Department of Pathology, University of Alabama at Birmingham, USA.
J Neuropathol Exp Neurol. 1999 Jul;58(7):679-90. doi: 10.1097/00005072-199907000-00001.
This review of brain changes in schizophrenia provides the neuropathologist with a conceptual framework to understand this disease. Numerous conflicting reports describe structural, functional, neurochemical, and neuropathological alterations in brains of schizophrenic patients. A core clinical manifestation of schizophrenia is disruption of thought; a mental process that is poorly localized in the brain and influenced by multiple neural systems. Schizophrenia has variable clinical presentations, natural history, and response to medication that imply a pathologically heterogenous group of diseases. Recent studies suggest that schizophrenia may involve cortical, limbic, and subcortical structures as well as multiple neurotransmitter systems. Schizophrenia may result from a perinatal insult in a genetically predisposed individual that produces neuronal alterations that manifest during final synaptic reorganization and myelination of early adulthood.
这篇关于精神分裂症大脑变化的综述为神经病理学家提供了一个理解这种疾病的概念框架。众多相互矛盾的报告描述了精神分裂症患者大脑中的结构、功能、神经化学和神经病理学改变。精神分裂症的一个核心临床表现是思维紊乱；思维这一心理过程在大脑中的定位不明确，且受多个神经系统影响。精神分裂症有多种临床表现、自然病程及对药物的反应，这意味着它是一组病理异质性疾病。最近的研究表明，精神分裂症可能涉及皮质、边缘系统和皮质下结构以及多个神经递质系统。精神分裂症可能是由于在具有遗传易感性的个体中发生围产期损伤，导致神经元改变，这些改变在成年早期最终的突触重组和髓鞘形成过程中显现出来。
