Boyd A S, Stasko T, King L E, Cameron G S, Pearse A D, Gaskell S A
Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232-7270, USA.
J Am Acad Dermatol. 1999 Jul;41(1):23-6. doi: 10.1016/s0190-9622(99)70400-7.
Clinical features of the skin in persons who smoke include increased wrinkling, gauntness, and discoloration that has been termed smoker's face. The histologic changes in the sun-exposed skin of these patients have not been previously elucidated.
The purpose of this study was to assess the amount of elastosis in the sun-exposed skin of smokers and nonsmokers.
We evaluated the skin from the forehead and cheeks of 17 smokers and 14 nonsmokers for the presence of elastosis. With the use of a computer-generated analysis of tissue sections at 4 different levels, the amount of elastotic material was expressed as an average percent of the field staining for elastic tissue. Patients were also evaluated for the presence of other malignancies, arsenic and radiation exposure, and previous skin cancers.
There was a significantly greater amount of elastosis (P < .05) in the skin of patients who smoked compared with those patients who did not. No significant differences were found between the 2 groups with regard to the other parameters evaluated.
Cigarette smoking is associated with an increase in elastosis, which may contribute to the clinical features of "smoker's face."
吸烟者皮肤的临床特征包括皱纹增多、面容憔悴以及被称为“烟民脸”的色素沉着。此前尚未阐明这些患者暴露于阳光下的皮肤的组织学变化。
本研究的目的是评估吸烟者和非吸烟者暴露于阳光下的皮肤中弹性组织变性的程度。
我们评估了17名吸烟者和14名非吸烟者前额和脸颊皮肤的弹性组织变性情况。通过对4个不同层面的组织切片进行计算机生成分析，弹性组织变性物质的量以弹性组织染色区域的平均百分比表示。还对患者是否存在其他恶性肿瘤、砷和辐射暴露以及既往皮肤癌进行了评估。
与不吸烟者相比，吸烟者皮肤中的弹性组织变性量显著更多（P < 0.05）。在评估的其他参数方面，两组之间未发现显著差异。
吸烟与弹性组织变性增加有关，这可能导致“烟民脸”的临床特征。
