一氧化氮有助于果蝇对低氧的行为、细胞和发育反应。
Nitric oxide contributes to behavioral, cellular, and developmental responses to low oxygen in Drosophila.
作者信息
Wingrove J A, O'Farrell P H
机构信息
Department of Biochemistry and Biophysics, University of California, San Francisco, 94143-0448, USA.
出版信息
Cell. 1999 Jul 9;98(1):105-14. doi: 10.1016/S0092-8674(00)80610-8.
Abstract
A nitric oxide (NO)/cyclic GMP (cGMP) signaling pathway is thought to play an important role in mammalian vasodilation during hypoxia. We show that Drosophila utilizes components of this pathway to respond to hypoxia. Hypoxic exposure rapidly induced exploratory behavior in larvae and arrested the cell cycle. These behavioral and cellular responses were diminished by an inhibitor of NO synthase and by a polymorphism affecting a form of cGMP-dependent protein kinase. Conversely, these responses were induced by ectopic expression of NO synthase. Perturbing components of the NO/cGMP pathway altered both tracheal development and survival during prolonged hypoxia. These results indicate that NO and protein kinase G contribute to Drosophila's ability to respond to oxygen deprivation.
摘要
一氧化氮（NO）/环磷酸鸟苷（cGMP）信号通路被认为在哺乳动物缺氧期间的血管舒张中起重要作用。我们发现果蝇利用该信号通路的组分来应对缺氧。低氧暴露迅速诱导幼虫的探索行为并使细胞周期停滞。一氧化氮合酶抑制剂和影响一种cGMP依赖性蛋白激酶形式的多态性会减弱这些行为和细胞反应。相反，一氧化氮合酶的异位表达会诱导这些反应。干扰NO/cGMP信号通路的组分在长时间缺氧期间会改变气管发育和存活率。这些结果表明，NO和蛋白激酶G有助于果蝇应对缺氧的能力。
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Nitric oxide effects on cell growth: GMP-dependent stimulation of the AP-1 transcription complex and cyclic GMP-independent slowing of cell cycling.一氧化氮对细胞生长的影响：对AP-1转录复合体的鸟苷酸环化酶依赖性刺激以及对细胞周期的非环鸟苷酸依赖性减缓。
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