Shibata M, Kibe T, Fujimoto S, Ishikawa T, Murakami M, Ichiki T, Wada Y
Department of Pediatric, Nagoya City University Medical School, Nagoya, Japan.
Brain Dev. 1999 Jul;21(5):337-40. doi: 10.1016/s0387-7604(99)00027-3.
We described an 11-year-old girl with acute central nervous system lupus showing diffuse lesions. She developed generalized convulsions followed by prolonged coma, and her psychomotor ability recovered fully after 3 months of steroid therapy. Cranial magnetic resonance imaging (MRI) showed high signal intensity in the cerebral deep white matter, bilateral basal ganglia, thalami, and brainstem on T2-weighted image. These lesions resolved over 1 month with residual atrophic change in the heads of the caudate nucleus on MRI. Acute SLE leukoencephalopathy may be recognized as a subtype of CNS lupus.
我们描述了一名11岁患有急性中枢神经系统狼疮且有弥漫性病变的女孩。她出现全身性惊厥，随后陷入长时间昏迷，在接受3个月的类固醇治疗后，其精神运动能力完全恢复。头颅磁共振成像（MRI）显示，在T2加权图像上，脑深部白质、双侧基底神经节、丘脑和脑干呈高信号强度。这些病变在1个月内消退，MRI显示尾状核头部有残留萎缩性改变。急性系统性红斑狼疮性白质脑病可被视为中枢神经系统狼疮的一种亚型。
