Lizardo-Daudt H M, Albano Edelweiss M I
Center for Health Sciences, UNISNOS, Sao Leopoldo, RS, Brasil. hdaudtbios.unisinos.tche.br
Bol Chil Parasitol. 1998 Jul-Dec;53(3-4):52-7.
In the present study we investigated the ultrastructural alterations occurring in the renal glomeruli of sheep with hydatidosis. Renal samples from 39 sheep, 34 with hydatidosis and 5 without parasitosis, were examined by transmission electron microscopy. Additionally, biochemical analysis was performed by determining serum concentrations of creatinine, urea, total protein and albumin. The ultrastructural alterations identified were the presence of dense mesangial, subendothelial and intra-membranous deposits, mesangial cell proliferation with areas showing segmental sclerosis and interposition of mesangial cells with the formation of a neomembrane. Biochemical analysis revealed a significant increase in total serum protein in the experimental group compared with the control. Our results demonstrated that glomerulonephritis associated with hydatidosis in sheep can be classified into four categories: minimal lesions, mesangial glomerulonephritis, segmental and focal glomerulonephritis and membranoproliferative glomerulonephritis, being membranoproliferative and mesangial glomerulonephritis the most predominant categories.
在本研究中，我们调查了患有包虫病的绵羊肾小球发生的超微结构改变。通过透射电子显微镜检查了39只绵羊的肾脏样本，其中34只患有包虫病，5只未感染寄生虫。此外，通过测定血清肌酐、尿素、总蛋白和白蛋白浓度进行生化分析。所确定的超微结构改变包括致密的系膜、内皮下和膜内沉积物的存在，系膜细胞增殖，出现节段性硬化区域以及系膜细胞插入并形成新膜。生化分析显示，与对照组相比，实验组的血清总蛋白显著增加。我们的结果表明，绵羊中与包虫病相关的肾小球肾炎可分为四类：轻微病变、系膜增生性肾小球肾炎、节段性和局灶性肾小球肾炎以及膜增生性肾小球肾炎，其中膜增生性和系膜增生性肾小球肾炎最为常见。
