Angus K W, Gardiner A C, Mitchell B, Thomson D
J Pathol. 1980 May;131(1):65-74. doi: 10.1002/path.1711310106.
Renal biopsies were obtained by laparotomy from eight newborn C3 deficient Finnish Landrace lambs, and examined by light, electron and immunofluorescence microscopy. The capillaries of all glomeruli contained numerous neutrophils and peripheral capillary walls were thickened and refractile at high magnifications. Almost continuous subendothelial electron-dense deposits were seen in peripheral capillary walls. Large amounts of C'3, and small amounts of IgM and IgA were also seen in these sits. No IgG was seen in these glomeruli. Four lambs died within 96 hr of birth. The remaining four lambs all had severe clinical mesangiocapillary glomerulonephritis (MCGN) by 21 to 42 days after birth. Amounts of C'3, IgM and IgA in glomeruli had increased by comparison with amounts at birth, and IgG was present in the deposits. It was concluded that the processes ultimately expressed as MCGN in these lambs were initiated before birth.
通过剖腹术从八只新生的C3缺陷型芬兰长白羔羊身上获取肾活检组织，并进行光镜、电镜和免疫荧光显微镜检查。所有肾小球的毛细血管内都有大量中性粒细胞，高倍镜下可见外周毛细血管壁增厚且有折光性。在外周毛细血管壁可见几乎连续的内皮下电子致密沉积物。在这些部位还可见大量C'3以及少量IgM和IgA。在这些肾小球中未见IgG。四只羔羊在出生后96小时内死亡。其余四只羔羊在出生后21至42天均患有严重的临床系膜毛细血管性肾小球肾炎（MCGN）。与出生时相比，肾小球中C'3、IgM和IgA的量增加，沉积物中出现了IgG。得出的结论是，这些羔羊最终表现为MCGN的过程在出生前就已开始。
