Okada H, Konishi K, Suzuki H, Saruta T, Sakaguchi H
Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
Clin Nephrol. 1994 Jun;41(6):338-41.
A 32-year-old Japanese male presented with abundant proteinuria, and renal biopsy revealed diffuse subendothelial and mesangial deposits in the glomeruli without hypercellularity or mesangial interposition. There was no clinical or laboratory evidence of systemic conditions such as collagen-vascular disease, paraproteinemia, or infection. Treatment with corticosteroid was ineffective and the patient eventually went into end-stage renal failure. To our knowledge, this is the first report of an idiopathic progressive glomerulopathy characterized by diffuse, global subendothelial and mesangial deposits, which suggests to us a novel insight into glomerular subendothelial/mesangial deposition.
一名32岁的日本男性出现大量蛋白尿，肾活检显示肾小球内有弥漫性内皮下和系膜沉积，无细胞增多或系膜插入。没有胶原血管病、副蛋白血症或感染等全身性疾病的临床或实验室证据。皮质类固醇治疗无效，患者最终发展为终末期肾衰竭。据我们所知，这是第一例以弥漫性、全身性内皮下和系膜沉积为特征的特发性进行性肾小球病的报告，这为我们对肾小球内皮下/系膜沉积提供了新的见解。
