O'Malley K J, Flechner S M, Kapoor A, Rhodes R A, Modlin C S, Goldfarb D A, Novick A C
Department of Urology, Cleveland Clinic Foundation, Ohio 44195, USA.
Am J Surg. 1999 Jun;177(6):492-6. doi: 10.1016/s0002-9610(99)00093-8.
Acute colonic pseudo-obstruction (Ogilvie's syndrome) in the immunosuppressed patient is associated with increased morbidity and mortality. Renal transplant recipients possess several comorbidities that increase the risk of acute pseudo-obstruction of the colon. The aims of this study were to present our experience with this syndrome and to evaluate the potentiating factors in these patients. A review of the literature for pseudo-obstruction following renal transplantation is presented.
Seven patients who developed Ogilvie's syndrome were identified in a retrospective review of 550 kidney-only transplants. Pretransplant data, potential risk factors, presentation, management, and outcome details were retrieved. The medical literature was reviewed using Medline.
Seventy-eight patients with Ogilvie's syndrome in the early posttransplant period have been reported. The associated morbidity and mortality was heightened in this immunocompromised population. Obese transplant recipients (body mass index >30 kg/m2) were at significantly increased risk for developing this syndrome.
A broad armamentarium of treatment options is available, but the key to successful resolution lies in early recognition.
免疫抑制患者的急性结肠假性梗阻（奥吉尔维综合征）与发病率和死亡率增加相关。肾移植受者存在多种合并症，增加了结肠急性假性梗阻的风险。本研究的目的是介绍我们对该综合征的经验，并评估这些患者中的促发因素。同时对肾移植后假性梗阻的文献进行综述。
在对550例单纯肾移植的回顾性研究中，确定了7例发生奥吉尔维综合征的患者。检索了移植前数据、潜在危险因素、临床表现、治疗方法及结果细节。使用Medline对医学文献进行了综述。
已有报道78例患者在移植后早期发生奥吉尔维综合征。在这个免疫功能低下的人群中，相关的发病率和死亡率有所增加。肥胖的移植受者（体重指数>30kg/m²）发生该综合征的风险显著增加。
有多种治疗方法可供选择，但成功解决问题的关键在于早期识别。
