Saito S, Iwaki H
Art Park Urology Hospital and Clinic, Department of Pathology, Sapporo Medical University, Japan.
Urology. 1999 Jul;54(1):141-4. doi: 10.1016/s0090-4295(98)00595-0.
To report on a case of mucinous carcinoma of the prostate and discuss the clinical and histopathologic features of the mucin-producing carcinoma of the prostate from a review of published reports.
Our case and 87 other previously reported cases were evaluated clinically and histologically.
We encountered a case of mucinous carcinoma of the prostate, Stage C, which was treated by radical prostatectomy. After reviewing it and the 87 other cases, we believe that these cases of mucin-producing carcinomas can be divided into three groups: 60 cases of mucinous carcinoma, 17 cases of primary signet-ring cell carcinoma, and 11 cases of mucinous carcinoma with signet-ring cells. Mucinous carcinoma is a variant of high-grade adenocarcinoma of the prostate, wherein there is a 77.8% rate of prostate-specific antigen elevation and a similar rate (77.8%) of response to endocrine therapy. Fifty percent of patients survived 3 years and 25%, 5 years. In contrast, primary signet-ring cell carcinoma conveys one of the worst prognoses among patients with prostate cancer. There are no reliable tumor markers, and there was no response to endocrine therapy. Patients with primary signet-ring cell carcinoma had a 27.3% 3-year survival rate; none survived to 5 years. The clinical features of mucinous carcinoma with signet-ring cells are very similar to primary signet-ring cell carcinoma; again, there was no response to endocrine therapy and the 3-year survival rate was 16.7%.
Although it has been suggested that mucinous carcinoma is a variant of high-grade adenocarcinoma of the prostate, signet-ring cell carcinoma and mucinous carcinoma with signet-ring cells are other variants of carcinoma that develop in the prostate, and their prognoses are very poor.
报告一例前列腺黏液腺癌病例，并通过回顾已发表的报告来讨论前列腺黏液分泌癌的临床和组织病理学特征。
对我们的病例以及其他87例先前报道的病例进行临床和组织学评估。
我们遇到一例C期前列腺黏液腺癌病例，接受了根治性前列腺切除术。在对该病例和其他87例病例进行回顾后，我们认为这些黏液分泌癌病例可分为三组：黏液腺癌60例、原发性印戒细胞癌17例、伴有印戒细胞的黏液腺癌11例。黏液腺癌是前列腺高级别腺癌的一种变体，其中前列腺特异性抗原升高率为77.8%，对内分泌治疗的反应率相似（77.8%）。50%的患者存活3年，25%的患者存活5年。相比之下，原发性印戒细胞癌在前列腺癌患者中预后最差。没有可靠的肿瘤标志物，对内分泌治疗无反应。原发性印戒细胞癌患者的3年生存率为27.3%；无患者存活至5年。伴有印戒细胞的黏液腺癌的临床特征与原发性印戒细胞癌非常相似；同样，对内分泌治疗无反应，3年生存率为16.7%。
尽管有人认为黏液腺癌是前列腺高级别腺癌的一种变体，但印戒细胞癌和伴有印戒细胞的黏液腺癌是在前列腺中发生的其他癌变体，其预后非常差。
