Luo Shuai, Tian Xiaoxue, Xu Ting, Wang Jinjing
Department of Pathology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Front Oncol. 2024 Dec 11;14:1444541. doi: 10.3389/fonc.2024.1444541. eCollection 2024.
Signet-ring cell carcinoma (SRCC) originates from undifferentiated stem cells in the neck of glands within the lamina propria of the mucosa. Primarily affecting the stomach, SRCC can also involve the breast, pancreas, gallbladder, colon, and bladder, although these cases are rare. SRCC of the prostate is extremely rare, and diagnosing it pelvic puncture is particularly challenging. Prostate SRCC is a distinct type of malignant tumor characterized by unique biological behavior, high malignancy, rapid disease progression, and poor prognosis. Due to its rarity, early diagnosis and treatment are critical. Currently, the diagnosis and treatment of this disease present significant challenges.
A 74-year-old male patient was admitted to our hospital with "left lower abdominal pain, changes in bowel habits, and bloody stools for 2 months." A contrast-enhanced pelvic CT scan revealed a soft tissue density mass on the left side of the pelvis. Contrast-enhanced Pelvic MRI suggested a tumor with a rich blood supply on the left side of the pelvis, indistinguishable from the left seminal vesicle and prostate gland, indicating the presence of a suspected malignant tumor. Pathologic biopsy of the pelvic mass confirmed the diagnosis of prostate SRCC. The patient subsequently underwent chemoradiotherapy and has been followed up for three months. He is currently in good condition.
SRCC predominantly occurs in the digestive tract and rarely originates in the prostate. Diagnosing prostate SRCC through abdominal paracentesis is challenging. To the best of our knowledge, this is the first reported case of SRCC of the prostate initially presenting with gastrointestinal symptoms. Additionally, it presents a case of prostate SRCC involving the pelvis, confirmed through pelvic puncture. highlighting its significance for clinical diagnosis.
印戒细胞癌（SRCC）起源于黏膜固有层腺颈部的未分化干细胞。SRCC主要累及胃部，也可累及乳腺、胰腺、胆囊、结肠和膀胱，不过这些病例较为罕见。前列腺SRCC极为罕见，通过盆腔穿刺进行诊断极具挑战性。前列腺SRCC是一种独特类型的恶性肿瘤，具有独特的生物学行为、高恶性度、疾病进展迅速及预后不良的特点。由于其罕见性，早期诊断和治疗至关重要。目前，该疾病的诊断和治疗面临重大挑战。
一名74岁男性患者因“左下腹痛、排便习惯改变及便血2个月”入住我院。盆腔增强CT扫描显示盆腔左侧有一软组织密度肿块。盆腔增强MRI提示盆腔左侧有一血供丰富的肿瘤，与左侧精囊和前列腺难以区分，提示存在疑似恶性肿瘤。盆腔肿块的病理活检确诊为前列腺SRCC。患者随后接受了放化疗，并已随访3个月。他目前状况良好。
SRCC主要发生于消化道，很少起源于前列腺。通过腹部穿刺诊断前列腺SRCC具有挑战性。据我们所知，这是首例最初表现为胃肠道症状的前列腺SRCC报道病例。此外，它还展示了一例经盆腔穿刺确诊的累及盆腔的前列腺SRCC病例，凸显了其对临床诊断的意义。
