Tominaga K, Alstergren P, Kurita H, Kopp S
Department of Clinical Oral Physiology, Faculty of Dentistry, Karolinska Institutet, Huddinge, Sweden.
Arch Oral Biol. 1999 Jul;44(7):595-601. doi: 10.1016/s0003-9969(99)00026-6.
The aim was to investigate the joint perfusate concentration of serotonin (5-HT) in antigen-induced monoarthritis of the rabbit temporomandibular joint (TMJ) and knee joint. Thirty adult male New Zealand White rabbits, of whom eight were first used as healthy controls, were divided into TMJ and knee arthritis groups. Unilateral arthritis was induced with ovalbumin intra-articularly and the contralateral joint was sham-induced. The joints were perfused with saline (flow rate, 0.05 ml/min; 10-min intervals during 50 min) 3 weeks later and the 5-HT concentration analysed. After the perfusion, the joints were evaluated histologically. The 5-HT concentration in the initial perfusate from the arthritic TMJ was higher than in both sham-induced and healthy control joints, and from the knee joint arthritis higher than in sham-induced joints. No histological difference in the arthritis was observed between the two groups. This study shows that the 5-HT concentration found immediately after puncture is increased in antigen-induced arthritis of the rabbit TMJ and knee joint.
目的是研究兔颞下颌关节（TMJ）和膝关节抗原诱导性单关节炎中血清素（5-HT）的关节灌流液浓度。30只成年雄性新西兰白兔，其中8只首先用作健康对照，被分为TMJ和膝关节关节炎组。用卵清蛋白关节内注射诱导单侧关节炎，对侧关节进行假诱导。3周后用生理盐水灌注关节（流速，0.05 ml/min；50分钟内每隔10分钟一次），并分析5-HT浓度。灌注后，对关节进行组织学评估。来自关节炎性TMJ的初始灌流液中的5-HT浓度高于假诱导关节和健康对照关节，来自膝关节关节炎的5-HT浓度高于假诱导关节。两组之间在关节炎方面未观察到组织学差异。本研究表明，在兔TMJ和膝关节抗原诱导性关节炎中，穿刺后立即测得的5-HT浓度升高。
