La Ruche G, Leroy V, Mensah-Ado I, Ramon R, You B, Bergeron C, Mothebesoane-Anoh S, Touré-Coulibaly K, Dabis F
Programme National de Lutte contre le SIDA, Abidjan, Côte d'Ivoire.
Int J STD AIDS. 1999 Jun;10(6):363-8. doi: 10.1258/0956462991914276.
A prospective study in gynaecology clinics was conducted in Abidjan, Côte d'Ivoire, to assess the short-term evolution of squamous intraepithelial lesions (SILs). Of 94 women with a cytological diagnosis of SIL, 38 were infected with HIV. The average follow-up period after the initial smear was 5 months. Detection of human papillomavirus (HPV) by polymerase chain reaction (PCR) was performed at both the time of enrolment and final follow-up smear. There were 39 cases of persistent SILs. HIV-positive women had a higher percentage of persistent SIL (76%) than HIV-negative women (18%, relative risk (RR)=4.3, 95% confidence interval (CI) = 2.4, 7.7). SILs were more frequent among women infected with HPV at the time of enrolment or with persistent HPV infection, but these associations disappeared after adjusting for HIV serostatus. Spontaneous regression of SILs commonly occurs in HIV-negative African women. HIV-infected women with cervical dyskaryosis require gynaecology follow-up.
在科特迪瓦的阿比让的妇科诊所进行了一项前瞻性研究，以评估鳞状上皮内病变（SILs）的短期演变。在94例细胞学诊断为SIL的女性中，38例感染了艾滋病毒。初次涂片后的平均随访期为5个月。在入组时和最终随访涂片时均通过聚合酶链反应（PCR）检测人乳头瘤病毒（HPV）。有39例持续性SIL病例。艾滋病毒阳性女性的持续性SIL百分比（76%）高于艾滋病毒阴性女性（18%，相对风险（RR）=4.3，95%置信区间（CI）=2.4，7.7）。在入组时感染HPV或持续性HPV感染的女性中，SILs更常见，但在调整艾滋病毒血清学状态后，这些关联消失。SILs的自发消退在艾滋病毒阴性的非洲女性中很常见。患有宫颈核异质的艾滋病毒感染女性需要妇科随访。
