西非喀麦隆HIV阳性和HIV阴性育龄妇女中HPV的流行病学研究。
Epidemiology of HPV in HIV-positive and HIV-negative fertile women in Cameroon, West Africa.
作者信息
Desruisseau Andrew J, Schmidt-Grimminger Delf, Welty Edith
机构信息
Division of Infectious Diseases, Department of Internal Medicine, Meharry Medical College, 1005 Dr. DB Todd Jr Boulevard, Nashville, TN 37208, USA.
出版信息
Infect Dis Obstet Gynecol. 2009;2009:810596. doi: 10.1155/2009/810596. Epub 2010 Feb 9.
BACKGROUND
HPV types vary by country and HIV status. There are no data on the prevalent HPV genotypes from Cameroon.
METHODS
We conducted a cross-sectional, observational study on 65 Cameroonian women. Samples were sent for HPV genotyping and Thin Prep analyses.
RESULTS
41 out of 61 samples tested (67.2%) had HPV subtypes detected. The most common high risk types encountered were: 45 (24.6%) and 58 (21.5%). HIV-positive women were more likely to test positive for any HPV (P = .014), have more than one HPV subtype (P = .003), and to test positive for the high risk subtypes (P = .007). Of those with high risk HPV, HIV-positive women were more likely to have Thin Prep abnormalities than HIV-negative women (P = .013).
CONCLUSIONS
Oncogenic HPV subtypes 45 and 58 were more prevalent than those subtypes carried in the quadrivalent vaccine. Further studies are needed to assess whether the current vaccine will be effective in this region.
背景
人乳头瘤病毒（HPV）的类型因国家和艾滋病病毒（HIV）感染状况而异。喀麦隆尚无关于流行HPV基因型的数据。
方法
我们对65名喀麦隆女性进行了一项横断面观察性研究。样本被送去进行HPV基因分型和薄层液基制片分析。
结果
在检测的61个样本中，有41个（67.2%）检测到HPV亚型。最常见的高危型别为：45型（24.6%）和58型（21.5%）。HIV阳性女性更有可能HPV检测呈阳性（P = 0.014），感染不止一种HPV亚型（P = 0.003），且高危亚型检测呈阳性（P = 0.007）。在高危HPV感染者中，HIV阳性女性比HIV阴性女性更有可能出现薄层液基制片异常（P = 0.013）。
结论
致癌性HPV亚型45和58比四价疫苗所包含的亚型更为流行。需要进一步研究来评估当前疫苗在该地区是否有效。
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