Vernon S D, Unger E R, Piper M A, Severin S T, Wiktor S Z, Ghys P D, Miller D L, Horowitz I R, Greenberg A E, Reeves W C
Centers for Disease Control and Prevention, Department of Health and Human Services, Atlanta, GA 30333, USA.
Sex Transm Infect. 1999 Aug;75(4):258-60. doi: 10.1136/sti.75.4.258.
To explore whether HIV types 1 and 2 and CD4 cell count affect cervical neoplasia independent of human papillomavirus (HPV) in women with high or low numbers of sexual partners residing in Abidjan, Côte d'Ivoire.
The study population and methods are described in the companion paper. Additional methods include a Papanicolaou smear for cytological diagnosis and statistical analysis.
In maternal women, both HIV-1 and high risk HPV were significant independent risk factors for squamous intraepithelial lesions (SIL) (adjusted odds ratio (OR) 11.0 (95% CI 1.1-112) and 5.4 (1.5-18.8), respectively). Only high levels of HPV DNA in the lavage were associated with SIL (OR 13.2 (3.6-47.8)) in the maternal group. In female sex workers, high risk HPV was significantly associated with SIL (OR 23.7 (4.4-126)); HIV seropositivity was not. Any positive level (high or low amounts) of HPV DNA was significantly associated with SIL in sex workers (ORs 15.9 (3.3-76) and 12.7 (3.6-44), respectively). There was no association of SIL with CD4 cell counts < or = 500 x 10(6)/l in HIV seropositive women from either group.
HPV or HIV-1 infection independently affect cervical neoplasia in women with low numbers of sex partners.
探讨在居住于科特迪瓦阿比让的性伴侣数量多寡不同的女性中，1型和2型人类免疫缺陷病毒（HIV）以及CD4细胞计数是否独立于人类乳头瘤病毒（HPV）影响宫颈肿瘤的发生。
研究人群和方法在配套论文中进行了描述。其他方法包括采用巴氏涂片进行细胞学诊断和统计分析。
在孕妇中，HIV-1和高危型HPV均为鳞状上皮内病变（SIL）的显著独立危险因素（校正比值比（OR）分别为11.0（95%可信区间1.1 - 112）和5.4（1.5 - 18.8））。仅灌洗液中高水平的HPV DNA与孕妇组的SIL相关（OR 13.2（3.6 - 47.8））。在女性性工作者中，高危型HPV与SIL显著相关（OR 23.7（4.4 - 126））；HIV血清阳性则不然。HPV DNA的任何阳性水平（高或低量）均与女性性工作者的SIL显著相关（OR分别为15.9（3.3 - 76）和12.7（3.6 - 44））。两组HIV血清阳性女性中，SIL与CD4细胞计数≤500×10⁶/L均无关联。
HPV或HIV-1感染独立影响性伴侣数量少的女性的宫颈肿瘤发生。
