Hodgin U G
South Med J. 1975 Jul;68(7):817-23. doi: 10.1097/00007611-197507000-00006.
Fourteen patients with chronic osteomyelitis were treated with oral penicillin, oxacillin, or cloxacillin at a dose of 5 gm/day, plus 0.5 gm of probenecid (Benemid) three or four times per day. Treatment was continued for 2 1/2 to six months. In ten patients, evidence of osteomyelitis disappeared and there has been no recurrence during follow-up periods varying from six months to 2 1/2 years. Significant hepatotoxicity was encountered in two patients; one similar patient, not in this series but receiving a similar regimen of antibiotic, developed leukipenia. Thus, patients with chronic osteomyelitis appear to benefit from such a therapeutic program, but they must be monitored closely for hepatic or hematologic toxicity.
14例慢性骨髓炎患者接受了口服青霉素、苯唑西林或氯唑西林治疗，剂量为每日5克，加用丙磺舒（羧苯磺胺）0.5克，每日3或4次。治疗持续2.5至6个月。10例患者骨髓炎症状消失，在6个月至2.5年不等的随访期内无复发。2例患者出现明显的肝毒性；1例未纳入本系列但接受类似抗生素治疗方案的类似患者发生了白细胞减少症。因此，慢性骨髓炎患者似乎从这种治疗方案中获益，但必须密切监测其肝毒性或血液学毒性。
