Roy M N, Prince V E, Ho R K
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Mech Dev. 1999 Jul;85(1-2):27-34. doi: 10.1016/s0925-4773(99)00039-8.
Environmental influences are known to produce segmental defects in a variety of organisms. In this paper we report upon segmental aberrations produced by brief heat shocks delivered to developing zebrafish embryos. The initial defects in the segmental pattern of somitic boundaries and motoneuron axon outgrowth were usually observed five somites caudal to the somite which was forming at the time of heat shock application. Segmental defects in zebrafish embryos exposed to a single heat shock treatment can occur in a periodic pattern similar to the multiple disturbances observed to occur in chick embryos. These data are discussed with regard to models involving cell cycle synchrony or 'clock and wavefront' schemes in the process of somitogenesis.
已知环境影响会在多种生物体中产生节段性缺陷。在本文中，我们报告了对发育中的斑马鱼胚胎进行短暂热休克所产生的节段畸变。体节边界和运动神经元轴突生长的节段模式的初始缺陷通常在热休克施加时正在形成的体节尾侧五个体节处观察到。暴露于单次热休克处理的斑马鱼胚胎中的节段缺陷可能以类似于在鸡胚胎中观察到的多种干扰的周期性模式出现。本文就体节发生过程中涉及细胞周期同步或“时钟和波前”机制的模型对这些数据进行了讨论。
