Dearfield K L, McCarroll N E, Protzel A, Stack H F, Jackson M A, Waters M D
U.S. Environmental Protection Agency, Office of Research and Development (8103R), Washington, DC 20460, USA.
Mutat Res. 1999 Jul 15;443(1-2):183-221. doi: 10.1016/s1383-5742(99)00019-8.
With this effort, we continue our examination of data on selected pesticide chemicals and their related analogues that have been presented to the U.S. Environmental Protection Agency's (USEPA's) Office of Pesticide Programs (OPP). This report focuses on a group of selected chloroacetanilides and a few related compounds. As part of the registration process for pesticidal chemicals, interested parties (registrants) must submit toxicity information to support the registration including both mutagenicity and carcinogenicity data. Although this information is available to the public via Freedom of Information (FOI) requests to the OPP, publication in the scientific literature allows greater dissemination and examination of the data. For this Special Issue, graphic profiles have been prepared of the mutagenicity and carcinogenicity data available in the submissions to OPP. Also, a discussion is presented about how toxicity data are used to help establish tolerances (limits of pesticide residues in foods). The mutagenicity results submitted by registrants are supplemented by data on these chemicals from the open literature to provide a full perspective of their genetic toxicology. The group of chloroacetanilides reviewed here display a consistent pattern of mutagenic activity, probably mediated via metabolites. This mutagenic activity is a mechanistically plausible factor in the development of tumors seen in experimental animals exposed to this class of chemicals.
通过这项工作，我们继续对已提交给美国环境保护局（USEPA）农药项目办公室（OPP）的选定农药化学品及其相关类似物的数据进行审查。本报告重点关注一组选定的氯代乙酰苯胺和一些相关化合物。作为农药化学品注册过程的一部分，相关方（注册者）必须提交毒性信息以支持注册，包括致突变性和致癌性数据。尽管通过向OPP提出信息自由（FOI）请求，公众可以获取这些信息，但在科学文献中发表能使数据得到更广泛的传播和审查。对于本期特刊，已根据提交给OPP的材料中的致突变性和致癌性数据编制了图表简介。此外，还讨论了如何利用毒性数据来帮助确定耐受量（食品中农药残留的限量）。注册者提交的致突变性结果由公开文献中关于这些化学品的数据补充，以全面了解其遗传毒理学。此处审查的氯代乙酰苯胺类显示出一致的致突变活性模式，可能是由代谢物介导的。这种致突变活性是在接触此类化学品的实验动物中观察到的肿瘤发生过程中一个机制上合理的因素。
