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Matrix metalloproteinase inhibitor CGS 27023A protects COMP and proteoglycan in the bovine articular cartilage but not the release of their fragments from cartilage after prolonged stimulation in vitro with IL-1 alpha.

作者信息

Ganu V, Melton R, Wang W, Roberts D

机构信息

Novartis Institute for Biomedical Research, Summit, New Jersey 07901, USA.

出版信息

Ann N Y Acad Sci. 1999 Jun 30;878:607-11. doi: 10.1111/j.1749-6632.1999.tb07740.x.

DOI:10.1111/j.1749-6632.1999.tb07740.x
PMID:10415786
Abstract
摘要

相似文献

1
Matrix metalloproteinase inhibitor CGS 27023A protects COMP and proteoglycan in the bovine articular cartilage but not the release of their fragments from cartilage after prolonged stimulation in vitro with IL-1 alpha.基质金属蛋白酶抑制剂CGS 27023A可保护牛关节软骨中的软骨寡聚基质蛋白(COMP)和蛋白聚糖,但在体外经白细胞介素-1α长期刺激后,却无法保护它们的片段从软骨中释放出来。
Ann N Y Acad Sci. 1999 Jun 30;878:607-11. doi: 10.1111/j.1749-6632.1999.tb07740.x.
2
Oral administration of a matrix metalloproteinase inhibitor, CGS 27023A, protects the cartilage proteoglycan matrix in a partial meniscectomy model of osteoarthritis in rabbits.口服基质金属蛋白酶抑制剂CGS 27023A可保护兔骨关节炎部分半月板切除模型中的软骨蛋白聚糖基质。
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Inhibition of interleukin-1alpha-induced cartilage oligomeric matrix protein degradation in bovine articular cartilage by matrix metalloproteinase inhibitors: potential role for matrix metalloproteinases in the generation of cartilage oligomeric matrix protein fragments in arthritic synovial fluid.基质金属蛋白酶抑制剂对白细胞介素-1α诱导的牛关节软骨中软骨寡聚基质蛋白降解的抑制作用:基质金属蛋白酶在关节炎滑液中软骨寡聚基质蛋白片段生成中的潜在作用。
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A synthetic peptide metalloproteinase inhibitor, but not TIMP, prevents the breakdown of proteoglycan within articular cartilage in vitro.一种合成肽金属蛋白酶抑制剂而非组织金属蛋白酶抑制剂,可在体外防止关节软骨内蛋白聚糖的分解。
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Metalloprotease inhibitors halt collagen breakdown in IL-1 induced bovine nasal cartilage cultures.
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Effects of the hydroxamic acid derivate Ro 31-4724 on the metabolism and morphology of interleukin-1-treated cartilage explants.异羟肟酸衍生物Ro 31-4724对白细胞介素-1处理的软骨外植体代谢和形态的影响。
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Inhibition of articular cartilage degradation in culture by a novel nonpeptidic matrix metalloproteinase inhibitor.一种新型非肽类基质金属蛋白酶抑制剂对培养中关节软骨降解的抑制作用。
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Cleavage of cartilage oligomeric matrix protein (thrombospondin-5) by matrix metalloproteinases and a disintegrin and metalloproteinase with thrombospondin motifs.基质金属蛋白酶及含血小板反应蛋白基序的去整合素和金属蛋白酶对软骨寡聚基质蛋白(血小板反应蛋白-5)的裂解作用
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Effects of stromelysin activity on proteoglycan degradation of canine articular cartilage explants.基质溶素活性对犬关节软骨外植体蛋白聚糖降解的影响。
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Selective COX-2 inhibition prevents proinflammatory cytokine-induced cartilage damage.选择性COX-2抑制可预防促炎细胞因子诱导的软骨损伤。
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引用本文的文献

1
Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage.对ADAMTS4和MT4-MMP的分析表明,二者均参与白细胞介素-1处理的牛软骨中的蛋白聚糖分解。
Osteoarthritis Cartilage. 2005 Apr;13(4):269-77. doi: 10.1016/j.joca.2004.10.023.