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Metalloprotease inhibitors halt collagen breakdown in IL-1 induced bovine nasal cartilage cultures.

作者信息

Spirito S, Doughty J, O'Byrne E, Ganu V, Goldberg R L

机构信息

Ciba-Geigy Corp., Research Department, Summit, NJ 07901, USA.

出版信息

Inflamm Res. 1995 Aug;44 Suppl 2:S131-2. doi: 10.1007/BF01778297.

DOI:10.1007/BF01778297
PMID:8548363
Abstract
摘要

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Metalloprotease inhibitors halt collagen breakdown in IL-1 induced bovine nasal cartilage cultures.
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Cyclic tensile strain suppresses catabolic effects of interleukin-1beta in fibrochondrocytes from the temporomandibular joint.循环拉伸应变抑制颞下颌关节纤维软骨细胞中白细胞介素-1β的分解代谢作用。
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本文引用的文献

1
The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid.对含有少量这种亚氨基酸的组织和蛋白质样品中羟脯氨酸的测定。
Arch Biochem Biophys. 1961 May;93:440-7. doi: 10.1016/0003-9861(61)90291-0.
2
Biochemical and molecular characterization of stromelysin synthesized by human osteoarthritic chondrocytes stimulated with recombinant human interleukin-1.重组人白细胞介素-1刺激的人骨关节炎软骨细胞合成的基质溶解素的生化及分子特征
Clin Exp Rheumatol. 1994 Sep-Oct;12(5):489-96.
3
Effect of synthetic metalloprotease inhibitors on cartilage autolysis in vitro.
周期性拉伸应变在软骨细胞中作为白细胞介素-1β作用的拮抗剂。
J Immunol. 2000 Jul 1;165(1):453-60. doi: 10.4049/jimmunol.165.1.453.
合成金属蛋白酶抑制剂对体外软骨自溶的影响。
J Pharmacol Exp Ther. 1987 Feb;240(2):460-5.
4
Stimulation of procollagenase synthesis parallels increases in cellular procollagenase mRNA in human articular chondrocytes exposed to recombinant interleukin 1 beta or phorbol ester.在暴露于重组白细胞介素1β或佛波酯的人关节软骨细胞中，前胶原酶合成的刺激与细胞内前胶原酶mRNA的增加平行。
Biochem Biophys Res Commun. 1987 Apr 29;144(2):583-90. doi: 10.1016/s0006-291x(87)80006-2.
5
Insulin-like growth factor 1 can decrease degradation and promote synthesis of proteoglycan in cartilage exposed to cytokines.胰岛素样生长因子1可减少细胞因子作用下软骨中蛋白聚糖的降解并促进其合成。
Biochem J. 1989 Jun 1;260(2):543-8. doi: 10.1042/bj2600543.
6
An improved method for determining proteoglycans synthesized by chondrocytes in culture.一种用于测定培养的软骨细胞合成蛋白聚糖的改进方法。
Connect Tissue Res. 1990;24(3-4):265-75. doi: 10.3109/03008209009152154.
7
Catabolism of aggrecan in cartilage explants. Identification of a major cleavage site within the interglobular domain.软骨外植体中聚集蛋白聚糖的分解代谢。球间结构域内一个主要切割位点的鉴定。
J Biol Chem. 1991 May 15;266(14):8683-5.
8
Potent collagenase inhibitors prevent interleukin-1-induced cartilage degradation in vitro.强效胶原酶抑制剂可在体外防止白细胞介素-1诱导的软骨降解。
Int J Tissue React. 1991;13(5):237-41.