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Oral administration of a matrix metalloproteinase inhibitor, CGS 27023A, protects the cartilage proteoglycan matrix in a partial meniscectomy model of osteoarthritis in rabbits.

作者信息

O'Byrne E M, Parker D T, Roberts E D, Goldberg R L, MacPherson L J, Blancuzzi V, Wilson D, Singh H N, Ludewig R, Ganu V S

机构信息

Research Department, Ciba-Geigy Corporation, Summit, NJ 07901, USA.

出版信息

Inflamm Res. 1995 Aug;44 Suppl 2:S117-8. doi: 10.1007/BF01778290.

DOI:10.1007/BF01778290
PMID:8548356
Abstract
摘要

相似文献

1
Oral administration of a matrix metalloproteinase inhibitor, CGS 27023A, protects the cartilage proteoglycan matrix in a partial meniscectomy model of osteoarthritis in rabbits.口服基质金属蛋白酶抑制剂CGS 27023A可保护兔骨关节炎部分半月板切除模型中的软骨蛋白聚糖基质。
Inflamm Res. 1995 Aug;44 Suppl 2:S117-8. doi: 10.1007/BF01778290.
2
Matrix metalloproteinase inhibitor CGS 27023A protects COMP and proteoglycan in the bovine articular cartilage but not the release of their fragments from cartilage after prolonged stimulation in vitro with IL-1 alpha.基质金属蛋白酶抑制剂CGS 27023A可保护牛关节软骨中的软骨寡聚基质蛋白（COMP）和蛋白聚糖，但在体外经白细胞介素-1α长期刺激后，却无法保护它们的片段从软骨中释放出来。
Ann N Y Acad Sci. 1999 Jun 30;878:607-11. doi: 10.1111/j.1749-6632.1999.tb07740.x.
3
The effect of CGS 27023A on the level of 3B3 (-) epitope in a rabbit meniscectomy model.CGS 27023A对兔半月板切除术模型中3B3（-）表位水平的影响。
Inflamm Res. 1997 Aug;46 Suppl 2:S139-40. doi: 10.1007/s000110050144.
4
CGS 27023A. CDG 27023A.
Drugs R D. 1999 Feb;1(2):144-5. doi: 10.2165/00126839-199901020-00007.
5
Esculetin (dihydroxycoumarin) inhibits the production of matrix metalloproteinases in cartilage explants, and oral administration of its prodrug, CPA-926, suppresses cartilage destruction in rabbit experimental osteoarthritis.七叶亭（二羟基香豆素）可抑制软骨外植体中基质金属蛋白酶的产生，口服其前药CPA-926可抑制兔实验性骨关节炎中的软骨破坏。
J Rheumatol. 1999 Mar;26(3):654-62.
6
Biological evaluation of matrix metalloproteinase inhibitors, 18 May 1995, New York.基质金属蛋白酶抑制剂的生物学评估，1995年5月18日，纽约
Inflamm Res. 1995 Nov;44(11):458-60. doi: 10.1007/BF01837909.
7
Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits.CGS 27023A的发现，一种非肽类、强效且口服有效的基质溶解素抑制剂，可阻止兔子的软骨降解。
J Med Chem. 1997 Aug 1;40(16):2525-32. doi: 10.1021/jm960871c.
8
Effect of inhibition of matrix metalloproteinases on cartilage loss in vitro and in a guinea pig model of osteoarthritis.基质金属蛋白酶抑制对体外及豚鼠骨关节炎模型软骨损失的影响。
Arthritis Rheum. 2005 Jan;52(1):171-80. doi: 10.1002/art.20900.
9
Metalloprotease inhibitors halt collagen breakdown in IL-1 induced bovine nasal cartilage cultures.
Inflamm Res. 1995 Aug;44 Suppl 2:S131-2. doi: 10.1007/BF01778297.
10
Effect of food on the pharmacokinetics of oral MMI270B (CGS 27023A), a novel matrix metalloproteinase inhibitor.食物对新型基质金属蛋白酶抑制剂口服MMI270B（CGS 27023A）药代动力学的影响。
Clin Cancer Res. 2000 Feb;6(2):431-3.

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J Orthop Res. 2018 Apr 12;36(8):2076-86. doi: 10.1002/jor.23910.
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Results of single and repeat dose studies of the oral matrix metalloproteinase inhibitor marimastat in healthy male volunteers.口服基质金属蛋白酶抑制剂马立马司他在健康男性志愿者中的单剂量和重复剂量研究结果。
Br J Clin Pharmacol. 1998 Jan;45(1):21-6. doi: 10.1046/j.1365-2125.1998.00639.x.

本文引用的文献

1
Comparison of magnetic resonance imaging (MRI) and histopathology in rabbit models of osteoarthritis and immune arthritis.骨关节炎和免疫性关节炎兔模型中磁共振成像（MRI）与组织病理学的比较。
Agents Actions. 1993;39 Spec No:C157-9. doi: 10.1007/BF01972752.
2
Prostromelysin and procollagenase genes are differentially up-regulated in chondrocytes from the knees of rabbits with experimental osteoarthritis.在实验性骨关节炎兔膝关节软骨细胞中，原基质溶解素基因和原胶原酶基因的上调存在差异。
Arthritis Rheum. 1994 Aug;37(8):1189-97. doi: 10.1002/art.1780370813.
3
A new model of osteoarthritis in rabbits. I. Development of knee joint pathology following lateral meniscectomy and section of the fibular collateral and sesamoid ligaments.
一种兔骨关节炎新模型。I. 外侧半月板切除术及腓侧副韧带和籽骨韧带切断术后膝关节病理变化的发展
Arthritis Rheum. 1983 Jul;26(7):875-86. doi: 10.1002/art.1780260709.
4
Morphometric quantitation of histopathologic changes in articular cartilage in an immunologically-induced rabbit model of rheumatoid arthritis.在类风湿性关节炎的免疫诱导兔模型中对关节软骨组织病理学变化进行形态计量学定量分析。
Lab Invest. 1987 Sep;57(3):342-6.
5
Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilage.人类骨关节炎软骨中金属蛋白酶与金属蛋白酶抑制剂失衡的证据。
J Clin Invest. 1989 Aug;84(2):678-85. doi: 10.1172/JCI114215.
6
Tetracyclines suppress matrix metalloproteinase activity in adjuvant arthritis and in combination with flurbiprofen, ameliorate bone damage.
J Rheumatol. 1992 Jun;19(6):927-38.