Weber R, Keerl R, Radziwill R, Schick B, Jaspersen D, Dshambazov K, Mlynski G, Draf W
Department of Otorhinolaryngology, Head and Neck Surgery, Facial Plastic Surgery and Communication Disorders, Fulda Hospital, Academic Teaching Hospital of the University of Marburg, Germany.
Rhinology. 1999 Jun;37(2):69-73.
Topical corticosteroids are one of the main pillars in the treatment of nasal polyps. The exact topography of their intranasal deposition has not yet been adequately visualised. The intranasal distribution of a 1% sodium fluorescein solution applied with original Pulmicort Topinasal (budesonide) metered pump bottles was analysed by videoendoscopy. The study group included eight healthy subjects and ten patients who had undergone endonasal sinus surgery. Videoendoscopy was performed in the study group within the first minute after application of the fluorescein solution. Additionally the deposition pattern of Pulmicort Topinasal was analyzed using a nasal model. The examination showed that the majority of the substance is deposited on the anterior portion of the nasal septum and the head of the inferior turbinate. Only a small fraction actually reaches the middle meatus. The distribution is improved by application during the decongested phase of the nasal cycle, after use of vasoconstricting nasal drops and maintaining a spraying angle of 45 degrees upwards. The development of new delivery techniques and systems could improve the efficacy of intranasally administered corticosteroids and reduce the complication rate.
局部用皮质类固醇是治疗鼻息肉的主要支柱之一。其鼻内沉积的确切形态尚未得到充分的可视化呈现。通过视频内窥镜分析了使用原普米克令舒鼻用（布地奈德）定量泵瓶施用的1%荧光素钠溶液在鼻内的分布情况。研究组包括8名健康受试者和10名接受过鼻内鼻窦手术的患者。在研究组中，于施用荧光素溶液后的第一分钟内进行视频内窥镜检查。此外，使用鼻腔模型分析了普米克令舒鼻用的沉积模式。检查表明，大部分物质沉积在鼻中隔前部和下鼻甲头部。只有一小部分实际到达中鼻道。在鼻周期的充血期、使用血管收缩滴鼻剂后以及保持向上45度的喷雾角度进行施用时，分布情况会得到改善。新给药技术和系统的开发可以提高鼻内施用皮质类固醇的疗效并降低并发症发生率。
