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一种识别预测的蜱传脑炎病毒E蛋白融合序列的单克隆抗体可阻断融合。

A monoclonal antibody that recognizes the predicted tick-borne encephalitis virus E protein fusion sequence blocks fusion.

作者信息

Volkova T D, Vorovitch M F, Ivanov V T, Timofeev A V, Volpina O M

机构信息

Shimyakin and Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia.

出版信息

Arch Virol. 1999;144(5):1035-9. doi: 10.1007/s007050050566.

DOI:10.1007/s007050050566
PMID:10416385
Abstract

The fusion motif of tick-borne encephalitis virus E protein has been predicted to be located within its conserved region (98-120). Results are presented to demonstrate that non-neutralizing monoclonal antibody which recognizes a synthetic peptide corresponding to residues 98-113 of the E protein sequence can block the fusion of the virus particles with artificial membranes.

摘要

蜱传脑炎病毒E蛋白的融合基序预计位于其保守区域(98-120)内。本文给出的结果表明,识别与E蛋白序列98-113位残基对应的合成肽的非中和性单克隆抗体可阻断病毒颗粒与人工膜的融合。

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A monoclonal antibody that recognizes the predicted tick-borne encephalitis virus E protein fusion sequence blocks fusion.一种识别预测的蜱传脑炎病毒E蛋白融合序列的单克隆抗体可阻断融合。
Arch Virol. 1999;144(5):1035-9. doi: 10.1007/s007050050566.
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[Protein E 98-113 sequence is a fusion site of tick-borne encephalitis virus with cellular membrane].[蛋白质E 98 - 113序列是蜱传脑炎病毒与细胞膜的融合位点]
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Intranasal immunization with inactivated tick-borne encephalitis virus and the antigenic peptide 89-119 protects mice against intraperitoneal challenge.用灭活的蜱传脑炎病毒和抗原肽89-119进行鼻内免疫可保护小鼠免受腹腔内攻击。
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引用本文的文献

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A broadly flavivirus cross-neutralizing monoclonal antibody that recognizes a novel epitope within the fusion loop of E protein.一种广谱黄病毒中和单克隆抗体,识别 E 蛋白融合环内的新表位。
PLoS One. 2011 Jan 11;6(1):e16059. doi: 10.1371/journal.pone.0016059.
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Mutational evidence for an internal fusion peptide in flavivirus envelope protein E.黄病毒包膜蛋白E中存在内部融合肽的突变证据。
J Virol. 2001 May;75(9):4268-75. doi: 10.1128/JVI.75.9.4268-4275.2001.
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Structures and mechanisms in flavivirus fusion.黄病毒融合中的结构与机制。
Adv Virus Res. 2000;55:231-69. doi: 10.1016/s0065-3527(00)55005-2.