Volkova T D, Vorovitch M F, Ivanov V T, Timofeev A V, Volpina O M
Shimyakin and Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia.
Arch Virol. 1999;144(5):1035-9. doi: 10.1007/s007050050566.
The fusion motif of tick-borne encephalitis virus E protein has been predicted to be located within its conserved region (98-120). Results are presented to demonstrate that non-neutralizing monoclonal antibody which recognizes a synthetic peptide corresponding to residues 98-113 of the E protein sequence can block the fusion of the virus particles with artificial membranes.
蜱传脑炎病毒E蛋白的融合基序预计位于其保守区域(98-120)内。本文给出的结果表明,识别与E蛋白序列98-113位残基对应的合成肽的非中和性单克隆抗体可阻断病毒颗粒与人工膜的融合。