Stumvoll M, Meyer C, Mitrakou A, Gerich J E
Medizinische Universitätsklinik, Tübingen, Germany.
Med Hypotheses. 1999 May;52(5):363-6. doi: 10.1054/mehy.1997.0655.
Recent studies using a combination of isotope and balance techniques have shown that, in the postabsorptive state, the human kidney contributes substantially to overall glucose production and consumption. The kidney may contribute as much as the liver to gluconeogenesis and play an important role in the counterregulation of hypoglycemia. Furthermore, increased renal glucose production may contribute to fasting hyperglycemia found in type I and type II diabetes mellitus. Finally, loss of renal tissue as a consumer of glucose could explain the insulin resistance of uremia. We hypothesize that the human kidney may play a more important role in human carbohydrate metabolism than previously appreciated.
最近结合同位素和平衡技术的研究表明，在吸收后状态下，人体肾脏对总体葡萄糖的产生和消耗有很大贡献。肾脏在糖异生方面的作用可能与肝脏相当，并在低血糖的对抗调节中发挥重要作用。此外，肾脏葡萄糖生成增加可能导致I型和II型糖尿病患者出现空腹高血糖。最后，肾脏组织作为葡萄糖消耗者的丧失可以解释尿毒症的胰岛素抵抗。我们推测，人体肾脏在人类碳水化合物代谢中可能发挥着比以往认识到的更重要的作用。
