APS是一种具有PH和SH2结构域的衔接蛋白，是胰岛素受体激酶的底物。
APS, an adapter protein with a PH and SH2 domain, is a substrate for the insulin receptor kinase.
作者信息
Ahmed Z, Smith B J, Kotani K, Wilden P, Pillay T S
机构信息
Molecular Endocrinology Group, Institute of Cell Signalling and School of Biomedical Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham NG7 2UH, U.K.
出版信息
Biochem J. 1999 Aug 1;341 ( Pt 3)(Pt 3):665-8.
Abstract
APS (adapter protein with a PH and SH2 domain) is the newest member of a family of tyrosine kinase adapter proteins including SH2-B and Lnk. We previously identified SH2-B as an insulin-receptor-binding protein and substrate [Kotani, Wilden and Pillay (1998) Biochem J. 335, 103-109]. Here we show that APS interacts with the insulin receptor kinase activation loop through its SH2 domain and insulin stimulates the tyrosine-phosphorylation of APS. Furthermore, the phosphorylation of activation-loop tyrosine residues 1158 and 1162 are required for this interaction.
摘要
APS（具有PH和SH2结构域的衔接蛋白）是包括SH2-B和Lnk在内的酪氨酸激酶衔接蛋白家族的最新成员。我们之前已鉴定出SH2-B是一种胰岛素受体结合蛋白和底物[小谷、威尔登和皮莱（1998年）《生物化学杂志》335卷，第103 - 109页]。在此我们表明，APS通过其SH2结构域与胰岛素受体激酶激活环相互作用，并且胰岛素刺激APS的酪氨酸磷酸化。此外，这种相互作用需要激活环酪氨酸残基1158和1162的磷酸化。
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本文引用的文献
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