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Binding of SH2 containing proteins to the insulin receptor: a new way for modulating insulin signalling.

作者信息

Liu F, Roth R A

机构信息

Department of Pharmacology, University of Texas Health Science Center at San Antonio, USA.

出版信息

Mol Cell Biochem. 1998 May;182(1-2):73-8.

PMID:9609116
Abstract

Prior studies have established a role in insulin action for the tyrosine phosphorylation of substrates and their subsequent complexing with SH2 containing proteins. More recently, SH2 proteins have been identified which can tightly bind to the tyrosine phosphorylated insulin receptor. The major protein identified so far (called Grb-IR or Grb10) of this type appears to be present in at least 3 isoforms, varying in the presence of a pleckstrin homology domain and in the sequence of its amino terminus. The binding of this protein to the insulin receptor appears to inhibit signalling by the receptor. The present review will discuss the current knowledge of the structure and function of this protein.

摘要

相似文献

1
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2
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Mol Endocrinol. 1998 May;12(5):688-97. doi: 10.1210/mend.12.5.0106.
6
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本文引用的文献

1
Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains.人GRB-IRbeta/GRB10。一种具有PH和SH2结构域的胰岛素和生长因子受体结合蛋白的剪接变体。
J Biol Chem. 1997 Jan 31;272(5):2659-67. doi: 10.1074/jbc.272.5.2659.
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Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor gamma.胰岛素和丝裂原活化蛋白激酶介导的过氧化物酶体增殖物激活受体γ的磷酸化与激活
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Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors.
通过甲基化敏感代表性差异分析揭示的小鼠近端11号和7号染色体的印记甲基化图谱。
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Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis.Grb10，一种在血小板衍生生长因子BB、胰岛素样生长因子I和胰岛素介导的有丝分裂中起正向刺激信号作用的衔接蛋白。
Mol Cell Biol. 1999 Sep;19(9):6217-28. doi: 10.1128/MCB.19.9.6217.
6
APS, an adapter protein with a PH and SH2 domain, is a substrate for the insulin receptor kinase.APS是一种具有PH和SH2结构域的衔接蛋白，是胰岛素受体激酶的底物。
Biochem J. 1999 Aug 1;341 ( Pt 3)(Pt 3):665-8.
Grb7是血小板衍生生长因子α受体和β受体的下游信号传导成分。
J Biol Chem. 1996 Nov 29;271(48):30942-9. doi: 10.1074/jbc.271.48.30942.
4
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J Biol Chem. 1996 Sep 20;271(38):23588-93. doi: 10.1074/jbc.271.38.23588.
5
Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling.一种GRB-IR剪接变体（人类GRB10同源物）与胰岛素及胰岛素样生长因子I受体的相互作用。有丝分裂信号传导中作用的证据。
J Biol Chem. 1996 Sep 13;271(37):22506-13. doi: 10.1074/jbc.271.37.22506.
6
Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10.胰岛素样生长因子I受体与IRS-1、Shc和Grb10直接相互作用的证据。
Mol Endocrinol. 1996 Jun;10(6):631-41. doi: 10.1210/mend.10.6.8776723.
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Grb10: A new substrate of the insulin-like growth factor I receptor.Grb10：胰岛素样生长因子I受体的一种新底物。
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Phosphatidylinositol 3-kinase inhibitors block differentiation of skeletal muscle cells.磷脂酰肌醇3-激酶抑制剂可阻断骨骼肌细胞的分化。
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Activated phosphatidylinositol 3-kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes.活化的磷脂酰肌醇3激酶足以介导3T3-L1脂肪细胞中的肌动蛋白重排和葡萄糖转运蛋白4易位。
J Biol Chem. 1996 Jul 26;271(30):17605-8. doi: 10.1074/jbc.271.30.17605.
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Cloning and characterization of GRB14, a novel member of the GRB7 gene family.GRB7基因家族新成员GRB14的克隆与特性分析
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