Nelson J S, Kelly K M
Beckman Laser Institute and Medical Clinic, Department of Surgery, University of California, Irvine, USA.
Dermatol Surg. 1999 Apr;25(4):274-6. doi: 10.1046/j.1524-4725.1999.08270.x.
The treatment of medium-sized (1.5-20 cm diameter) congenital melanocytic nevi (CMN) has been the concern of dermatologists for decades. Although many techniques have been described and utilized, no single treatment has emerged as applicable under all circumstances.
The Q-switched ruby laser (QSRL) at 694 nm, a wavelength well absorbed by melanin relative to other optically absorbing structures in skin, causes highly selective destruction of pigment-laden cells. In addition, the 20-nanosecond pulse duration produced by this laser approximates the thermal relaxation time for melanosomes, thereby confining the energy to the targeted cells.
In the present report, treatment using the QSRL resulted in complete clinical removal of a biopsy-documented medium-sized compound CMN with no recurrence after 5 years. In contrast to other therapeutic modalities, complications such has hypertrophic scarring, dyspigmentation, or atrophy were not observed.
几十年来，直径为1.5 - 20厘米的中等大小先天性黑素细胞痣（CMN）的治疗一直是皮肤科医生关注的问题。尽管已经描述并应用了许多技术，但没有一种单一的治疗方法在所有情况下都适用。
694纳米的调Q红宝石激光（QSRL），相对于皮肤中的其他光学吸收结构，该波长被黑色素高度吸收，可导致富含色素的细胞被高度选择性破坏。此外，该激光产生的20纳秒脉冲持续时间接近黑素小体的热弛豫时间，从而将能量限制在目标细胞内。
在本报告中，使用QSRL治疗导致经活检证实的中等大小复合型CMN临床完全清除，5年后无复发。与其他治疗方式不同，未观察到诸如肥厚性瘢痕、色素沉着异常或萎缩等并发症。
