Chang C J, Nelson J S, Achauer B M
Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taipei, Taiwan.
Plast Reconstr Surg. 1996 Oct;98(5):784-90. doi: 10.1097/00006534-199610000-00004.
The Q-switched ruby laser at 694 nm, a wavelength well absorbed by melanin relative to other optically absorbing structures in skin, causes highly selective destruction of pigment-laden cells. In addition, the 20- to 40-ns pulse duration produced by this laser approximates the thermal relaxation time for the melanosomes, thereby confining the energy to the target. The Q-switched ruby laser was used to treat 47 patients (11 males and 36 females) with nevus of Ota during the period December 1991 to 1994. The involved facial area ranged from 3 x 3 cm2 to 20 x 20 cm2. The energy fluence used varied from 8 to 10 J/cm2, and the number of treatments ranged from 1 to 8 (mean 3.4). The results were graded on the basis of cleaning and fading as follows: poor (0 to 25 percent), fair (26 to 50 percent), good (51 to 75 percent), and excellent (76 to 100 percent). The mean follow-up period was 15 months. Poor and/or fair results were found in 8 patients who received one treatment and 7 patients who had two treatments. Good results were seen in 1 patient who had two treatments, 7 patients who received three treatments, and 3 patients who had four treatments. Twenty-one patients had excellent results after three or more treatments of the whole lesion. In conclusion, this laser system produces clinically significant fading of nevus of Ota in patients without complications such as hypertrophic scarring or permanent changes in the normal skin pigmentation.
波长为694纳米的调Q红宝石激光，相对于皮肤中其他光吸收结构而言，该波长能被黑色素很好地吸收，可对充满色素的细胞造成高度选择性破坏。此外，这种激光产生的20至40纳秒脉冲持续时间接近黑素小体的热弛豫时间，从而将能量局限于目标部位。在1991年12月至1994年期间，使用调Q红宝石激光治疗了47例太田痣患者（11例男性和36例女性）。受累面部面积从3×3平方厘米到20×20平方厘米不等。所使用的能量密度从8到10焦每平方厘米不等，治疗次数从1到8次（平均3.4次）。根据清除和褪色情况将结果分为以下等级：差（0至25%）、一般（26至50%）、好（51至75%）和优（76至100%）。平均随访期为15个月。接受一次治疗的8例患者和接受两次治疗的7例患者出现差和/或一般的结果。接受两次治疗的1例患者、接受三次治疗的7例患者和接受四次治疗的3例患者出现好的结果。21例患者在对整个病变进行三次或更多次治疗后取得了优异的效果。总之，这种激光系统可使太田痣患者在临床上出现显著褪色，且无肥厚性瘢痕或正常皮肤色素永久性改变等并发症。
