福氏耐格里阿米巴所致原发性阿米巴脑膜脑炎：日本一例尸检病例
Primary amebic meningoencephalitis due to Naegleria fowleri: an autopsy case in Japan.
作者信息
Sugita Y, Fujii T, Hayashi I, Aoki T, Yokoyama T, Morimatsu M, Fukuma T, Takamiya Y
机构信息
Department of Pathology, Kurume University School of Medicine, Fukuoka-ken, Japan.
出版信息
Pathol Int. 1999 May;49(5):468-70. doi: 10.1046/j.1440-1827.1999.00893.x.
Free-living amebas represented by Naegleria fowleri, Acanthamoeba and Balamutia have been known to cause fatal meningoencephalitis since Fowler and Carter (1965) reported the first four human cases. An autopsy case of a 25-year-old female with primary amebic meningoencephalitis (PAM) due to Naegleria fowleri is described. Headache, lethargy and coma developed in this patient, and her condition progressed to death 8 days after the onset of clinical symptoms. Cerebral spinal fluid examination confirmed clusters of amebas, which were grown in culture and identified as Naegleria fowleri. At autopsy, lesions were seen in the central nervous system (CNS) and the ethmoid sinus. The CNS had severe, suppurative meningoencephalitis with amebic trophozoites mingled with macrophages. This case is the first report of PAM due to Naegleria fowleri in Japan.
自福勒和卡特（1965年）报告首例4例人类病例以来，以福氏耐格里阿米巴、棘阿米巴和巴拉姆希阿米巴为代表的自由生活阿米巴已知可导致致命性脑膜脑炎。本文描述了一例因福氏耐格里阿米巴导致原发性阿米巴脑膜脑炎（PAM）的25岁女性尸检病例。该患者出现头痛、嗜睡和昏迷，临床症状出现8天后病情进展至死亡。脑脊液检查证实存在阿米巴聚集物，其在培养中生长并被鉴定为福氏耐格里阿米巴。尸检时，在中枢神经系统（CNS）和筛窦发现病变。中枢神经系统有严重的化脓性脑膜脑炎，阿米巴滋养体与巨噬细胞混合存在。该病例是日本首例因福氏耐格里阿米巴导致的PAM报告。
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