Chang S S, Chau W K, Liu M T, Ho C H
Division of Hematology, Veterans General Hospital-Taipei, Taiwan, ROC.
Zhonghua Yi Xue Za Zhi (Taipei). 1999 Jul;62(7):467-71.
Sweet's syndrome is a cutaneous reactive process that is usually associated with fever, but rarely occurs in patients with hairy cell leukemia (HCL). We report the case of a patient with HCL who developed typical Sweet's syndrome five months after the diagnosis of HCL. Skin eruptions and constitutional symptoms subsided rapidly after short-term systemic adrenocorticosteroid treatment without recurrence, until the patient died from disease exacerbation and uncontrolled infection. According to his manifestations, chemical allergens, microorganisms or HCL progression were unlikely to have been the precipitating factors for development of Sweet's syndrome. Because immunologic disorders and opportunistic infection are not uncommon in patients with HCL, a skin biopsy should be taken as early as possible when cutaneous lesions and fever develop in order to establish a correct diagnosis. Hence, unnecessary and prolonged use of antibiotics is avoided and prompt relief of the symptoms by appropriate management can be achieved.
斯威特综合征是一种皮肤反应性疾病，通常伴有发热，但很少发生于毛细胞白血病（HCL）患者。我们报告1例HCL患者，在确诊HCL 5个月后发生了典型的斯威特综合征。短期全身应用肾上腺皮质类固醇治疗后，皮疹和全身症状迅速消退，未复发，直至患者因疾病加重和感染无法控制而死亡。根据其表现，化学过敏原、微生物或HCL进展不太可能是斯威特综合征发生的诱发因素。由于HCL患者免疫紊乱和机会性感染并不少见，当出现皮肤病变和发热时，应尽早进行皮肤活检以明确诊断。因此，可避免不必要的抗生素长期使用，并通过适当治疗迅速缓解症状。
