Reid C, Edwards J, Wang M, Manybeads Y, Mike L, Martinez N, La Grange L, Reyes E
Department of Behavioral Sciences, New Mexico Highlands University, Las Vegas, USA.
Planta Med. 1999 Jun;65(5):421-4. doi: 10.1055/s-1999-14085.
We explored the possibility that silymarin (SY), a fraction from Silybum marianum, might protect against the effects of in utero exposure to ethanol upon subsequent social memory function. Three groups of 8 pregnant female Sprague-Dawley rats each were provided with a liquid diet containing 35% ethanol derived calories (EDC). One experimental group received a daily subcutaneous injection of 400 mg/kg SY, the second, a 400 mg/kg oral dose of SY, a third group was maintained on the 35% EDC diet. A fourth group served as the pair-fed control group. The liquid diet regimen was maintained throughout pregnancy. Rats pups were fostered by dams in a fifth group that had been maintained on rat chow. At 90 days the pups were tested for social memory. Social recognition scores recorded for the ethanol pups were significantly poorer than those observed in both SY/ethanol groups and the chow group.
我们探究了水飞蓟宾（SY）（水飞蓟的一种提取物）是否有可能预防子宫内暴露于乙醇对后续社会记忆功能产生的影响。将三组，每组8只怀孕的雌性斯普拉格-道利大鼠给予含35%乙醇热量（EDC）的液体饮食。一个实验组每天皮下注射400mg/kg SY，第二个实验组口服400mg/kg SY，第三组维持35% EDC饮食。第四组作为配对喂养对照组。整个孕期维持液体饮食方案。第五组的幼崽由食用大鼠饲料的母鼠抚养。在90日龄时对幼崽进行社会记忆测试。记录到的乙醇组幼崽的社会识别分数明显低于SY/乙醇组和正常饮食组。
