Sellmayer A, Hrboticky N, Weber P C
Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Klinikum Innenstadt, University of Munich, Germany.
Lipids. 1999;34 Suppl:S13-8. doi: 10.1007/BF02562222.
Physiological and pathological vascular responses depend on the action of numerous intercellular mediators, ranging from hormones to gases like nitric oxide, proteins, and lipids. The last group consists not only of the different types of lipoproteins, but also includes a broad array of other lipophilic signaling molecules such as fatty acids, eicosanoids, phospholipids and their derivatives, sphingolipids and isoprenoids. Due to space limitations, it is impossible to discuss all the vascular effects of lipophilic mediators or compounds. Therefore, we will focus on one of the most important lipid-mediated diseases, atherosclerosis. Lipoproteins and especially their native or oxidized lipid compounds affect vascular function in many different ways, and these effects do not only modulate atherogenesis but are of paramount physiological and pathophysiological importance in other diseases, such as inflammation, tumor metastasis, or normal wound healing.
生理和病理血管反应取决于众多细胞间介质的作用，这些介质范围从激素到一氧化氮等气体、蛋白质和脂质。最后一组不仅包括不同类型的脂蛋白，还包括大量其他亲脂性信号分子，如脂肪酸、类二十烷酸、磷脂及其衍生物、鞘脂和类异戊二烯。由于篇幅限制，不可能讨论亲脂性介质或化合物的所有血管效应。因此，我们将重点关注最重要的脂质介导疾病之一——动脉粥样硬化。脂蛋白尤其是其天然或氧化脂质化合物以多种不同方式影响血管功能，这些作用不仅调节动脉粥样硬化的发生，而且在其他疾病如炎症、肿瘤转移或正常伤口愈合中具有至关重要的生理和病理生理意义。
