Su H M, Bernardo L, Mirmiran M, Ma X H, Nathanielsz P W, Brenna J T
Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA.
Lipids. 1999;34 Suppl:S347-50. doi: 10.1007/BF02562339.
The bioequivalence of dietary linolenic acid (LNA) and docosahexaenoic acid (DHA) for brain DHA accretion was measured in neonatal baboons at 4-6 wk of age using stable isotope tracers. Neonates consumed a conventional U.S. term-infant formula devoid of long chain polyunsaturates and with an n-6/n-3 ratio of about 10:1. At 4 wk of age, neonates were dosed with either 13C LNA or 13C DHA. At 6 wk of age, neonate brain, retina, and other organs were harvested for fatty acid and isotopic analyses. The relative accretion of labeled DHA was 7-fold greater as a percentage of dose for the DHA-dosed animals compared to the LNA-dosed animals. The baboon is an omnivore that regularly consumes meat and insects; its plasma lipid profile responds similarly to humans in response to changes in feeding and living habits. These observations suggest that the baboon is a suitable model for human unsaturated fatty acid studies.
使用稳定同位素示踪剂，在4至6周龄的新生狒狒中测量了膳食亚麻酸（LNA）和二十二碳六烯酸（DHA）对脑DHA积累的生物等效性。新生儿食用不含长链多不饱和脂肪酸且n-6/n-3比例约为10:1的传统美国足月儿配方奶粉。在4周龄时，给新生儿服用13C LNA或13C DHA。在6周龄时，采集新生儿的脑、视网膜和其他器官进行脂肪酸和同位素分析。与服用LNA的动物相比，服用DHA的动物中标记DHA的相对积累量作为剂量百分比要高7倍。狒狒是杂食动物，经常食用肉类和昆虫；其血浆脂质谱在对饮食和生活习惯变化的反应上与人类相似。这些观察结果表明，狒狒是人类不饱和脂肪酸研究的合适模型。
