Furuhashi M, Miyabe Y, Oda H
Department of Obstetrics and Gynecology, Handa City Hospital, Handa, 475-8599, Japan.
Gynecol Oncol. 1999 Aug;74(2):278-81. doi: 10.1006/gyno.1999.5428.
A case of ovarian carcinoma with thrombopoietin production is reported. A 49-year-old Japanese woman had serous cystadenocarcinoma of the right ovary with peritoneal spread. The platelet count was elevated to 432 x 10(9)/L. Enzyme-linked immunosorbent assay of the serum demonstrated remarkably high levels of thrombopoietin (2.96 fmol/ml). Immunohistochemical examination using an antibody specific for thrombopoietin revealed positive staining in the carcinoma cells, confirming thrombopoietin production.
报告了一例产生血小板生成素的卵巢癌病例。一名49岁的日本女性患有右卵巢浆液性囊腺癌并伴有腹膜播散。血小板计数升高至432×10⁹/L。血清酶联免疫吸附测定显示血小板生成素水平显著升高（2.96 fmol/ml）。使用针对血小板生成素的特异性抗体进行免疫组化检查，结果显示癌细胞呈阳性染色，证实有血小板生成素产生。
