Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA.
Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC 20052, USA.
Nutrients. 2023 Feb 3;15(3):781. doi: 10.3390/nu15030781.
Measures of cardiovascular health (CVH) assessed by a combination of behavioral and biological factors has shown protective associations with all-cause mortality. The mechanisms underlying these associations have not been fully elucidated. In this study, we characterized the plasma proteomics profile of CVH and tested whether specific proteins mediated the associations between CVH and all-cause mortality in participants of the InCHIANTI study. Of the 1301 proteins tested, 92 proteins were associated with CVH (22 positively, 70 negatively). Proteins most strongly associated with CVH included leptin (LEP), fatty acid binding protein 3 (FABP3), Angiopoietin-2 (ANGPT2), and growth-differential factor 15 (GDF15). Of the 92 CVH-associated proteins, 33 proteins significantly mediated the associations between CVH and all-cause mortality, with percent mediation ranging from 5 to 30%. The most significant mediating proteins were GDF15 and insulin-like growth factor 2 (IGFBP2). Proteins associated with better CVH were enriched for proteins that reflect the suppression of the complement coagulation and GH/IGF pathways.
心血管健康（CVH）的衡量标准是通过行为和生物因素的结合来评估的，它与全因死亡率呈保护相关。这些关联的机制尚未完全阐明。在这项研究中，我们对 CVH 的血浆蛋白质组学特征进行了描述，并测试了在 INCHIANTI 研究参与者中，特定蛋白质是否介导了 CVH 与全因死亡率之间的关联。在测试的 1301 种蛋白质中，有 92 种与 CVH 相关（22 种呈正相关，70 种呈负相关）。与 CVH 相关性最强的蛋白质包括瘦素（LEP）、脂肪酸结合蛋白 3（FABP3）、血管生成素-2（ANGPT2）和生长分化因子 15（GDF15）。在与 92 种 CVH 相关的蛋白质中，有 33 种蛋白质显著介导了 CVH 与全因死亡率之间的关联，中介百分比范围为 5%至 30%。最显著的中介蛋白质是 GDF15 和胰岛素样生长因子 2（IGFBP2）。与更好的 CVH 相关的蛋白质富含反映补体凝血和 GH/IGF 途径抑制的蛋白质。
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