免疫组织化学检测导致恶性肿瘤体液性高钙血症的皮肤鳞状细胞癌中的甲状旁腺激素相关蛋白。

Immunohistochemical detection of parathyroid hormone-related protein in a cutaneous squamous cell carcinoma causing humoral hypercalcemia of malignancy.

作者信息

Crespo M, Sopeña B, Orloff J J, Cameselle Teijeiro J F, Dann P, Andrade M A, Freire M, de la Fuente J, Martinez-Vazquez C

机构信息

Department of Internal Medicine, Hospital Xeral-Cíes, Vigo, Universidad de Santiago de Compostela, Spain.

出版信息

Arch Pathol Lab Med. 1999 Aug;123(8):725-30. doi: 10.5858/1999-123-0725-IDOPHR.

DOI:10.5858/1999-123-0725-IDOPHR

PMID:10420232

Abstract

Humoral hypercalcemia of malignancy is a cancer-related hypercalcemia caused by production of humoral factors by malignant cells in patients without bone metastases. Squamous cell carcinomas are the tumors most frequently associated with humoral hypercalcemia of malignancy, and parathyroid hormone-related protein is the main humoral factor implicated. In spite of the fact that normal keratinocytes produce parathyroid hormone-related protein, it is highly unusual for patients with squamous cell carcinomas of the skin to present with humoral hypercalcemia of malignancy. We present a well-documented case of cutaneous squamous cell carcinoma complicated by hypercalcemia in a patient with high levels of plasma parathyroid hormone-related protein and immunohistochemical evidence of high parathyroid hormone-related protein production by the tumoral cells.

摘要

恶性肿瘤相关性体液性高钙血症是一种与癌症相关的高钙血症，由无骨转移患者的恶性细胞产生体液因子所致。鳞状细胞癌是最常与恶性肿瘤相关性体液性高钙血症相关的肿瘤，甲状旁腺激素相关蛋白是主要涉及的体液因子。尽管正常角质形成细胞会产生甲状旁腺激素相关蛋白，但皮肤鳞状细胞癌患者出现恶性肿瘤相关性体液性高钙血症的情况非常罕见。我们报告一例有充分记录的皮肤鳞状细胞癌病例，该患者并发高钙血症，血浆甲状旁腺激素相关蛋白水平升高，且肿瘤细胞有甲状旁腺激素相关蛋白高表达的免疫组化证据。