Mori H, Aoki K, Katayama I, Nishioka K, Umeda T
Department of Dermatology (Unit of Plastic Surgery), Tokyo Medical and Dental University School of Medicine, Japan.
J Dermatol. 1996 Jul;23(7):460-2. doi: 10.1111/j.1346-8138.1996.tb04055.x.
A case of humoral hypercalcemia of malignancy in cutaneous squamous cell carcinoma is reported. An 82-year-old male underwent surgery for cutaneous squamous cell carcinoma (SCC) of the left hand in 1992. He subsequently developed clouding of consciousness with remarkable hypercalcemia, a high parathyroid hormone related protein (PTHrP) level, and elevated plasma cytokine levels [tumor necrosis factor alpha (TNF alpha), interleukin-6 (IL-6)]. Diagnosis of humoral hypercalcemia of malignancy (HHM) was made on the basis of these findings. He died of renal insufficiency due to this hypercalcemia in spite of several replacement therapies and chemotherapies. The PTHrP might have derived from the SCC and have been responsible for the HHM in conjunction with IL-6 and TNF alpha.
报告了一例皮肤鳞状细胞癌伴发恶性肿瘤性体液性高钙血症的病例。一名82岁男性于1992年接受了左手皮肤鳞状细胞癌（SCC）手术。随后，他出现意识模糊，伴有明显的高钙血症、甲状旁腺激素相关蛋白（PTHrP）水平升高以及血浆细胞因子水平升高[肿瘤坏死因子α（TNFα）、白细胞介素-6（IL-6）]。基于这些发现，诊断为恶性肿瘤性体液性高钙血症（HHM）。尽管进行了多种替代疗法和化疗，但他最终因这种高钙血症死于肾功能不全。PTHrP可能来源于SCC，并与IL-6和TNFα共同导致了HHM。
